197579-67-2

Upstream product

• 98-88-4 benzoyl chloride 
• 197579-66-1 4-Amino-5-hydroxy-1-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidin-2-one 
• 52278-77-0 5-Hydroxy-2'-deoxycytidine 
• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 

Downstream Products

• 197579-70-7 Benzoic acid 4-benzoylamino-1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-5-yl ester 
• 197579-69-4 Benzoic acid 4-benzoylamino-1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-5-yl ester 
• 197579-68-3 Benzoic acid 4-benzoylamino-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-5-yl ester 

Relevant academic research and scientific papers

A convenient synthesis of 5-hydroxy-2'-deoxycytidine phosphoramidite and its incorporation into oligonucleotides

Oligonucleotides containing 5-hydroxy-2'-deoxycytidine (2) have been synthesized using the phosphoramidite chemistry. The presence and the integrity of the modified nucleoside in the synthetic oligomers were confirmed by electrospray mass spectrometry and chromatographic analysis of enzymatic digestion coupled with W detection.