197588-25-3

Basic information

• Product Name: O-(3,5-difluorophenyl)hydroxylamine
• Synonyms: O-(3,5-difluorophenyl)hydroxylamine
• CAS NO: 197588-25-3
• Molecular Weight: 145.109
• Mol File: 197588-25-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: O-(3,5-difluorophenyl)hydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: O-(3,5-difluorophenyl)hydroxylamine(197588-25-3)
• EPA Substance Registry System: O-(3,5-difluorophenyl)hydroxylamine(197588-25-3)

Safety Data

• Hazardous Substances Data: 197588-25-3(Hazardous Substances Data)

Upstream product

• 2713-34-0 3,5-difluorophenol 
• 1239023-93-8 C₂₅H₁₁F₁₉N₂O₄ 
• 372-38-3 1,3,5-trifluorobenzene 
• 156545-07-2 3,5-difluorophenylboronic acid 

Downstream Products

• 1443440-60-5 N-(3,5-difluorophenoxy)acetamide 
• 75735-31-8 E-O-phenylbenzaldoxime 

Relevant articles and documents

Rhodium(III)-Catalyzed Cascade Redox-Neutral C–H Functionalization and Aromatization: Synthesis of Unsymmetrical ortho-Biphenols

An efficient rhodium(III)-catalyzed coupling reaction of N-aryloxyacetamides with 6-diazo-2-cyclohexenones through a cascade redox-neutral C–H functionalization and aromatization has been developed. This novel and scalable transformation provides a straightforward way to construct unsymmetrical ortho-biphenols with broad substrate scope under mild and redox-neutral conditions. The synthetic utility of this approach is demonstrated in the late-stage functionalization of bioactive compounds and the synthesis of an optically active ortho-biphenol. (Figure presented.).

Fluorous tagged N-hydroxy phthalimide for the parallel synthesis of O-aryloxyamines

The parallel synthesis of O-aryloxyamines remains an unfulfilled need in the field of medicinal chemistry and fragment-based approaches. To fill this gap a solution-phase two-step process based on (1) a copper-catalyzed cross-coupling of aryl boronic acid

Preparation of ring-substituted phenoxyamine derivatives

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