1976-85-8

Basic information

• Product Name: Uroporphyrinogen III
• Synonyms: Uroporphyrinogen III;2,7,12,18-Tetrakis(2-oxo-2-hydroxyethyl)-3,8,13,17-tetrakis(3-oxo-3-hydroxypropyl)-5,10,15,20,22,24-hexahydro-21H,23H-porphyrin;5,10,15,20,22,24-Hexahydrouroporphyrin III
• CAS NO: 1976-85-8
• Molecular Formula: C40H44N4O16
• Molecular Weight: 836.79456
• Mol File: 1976-85-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 1163.6°Cat760mmHg
• Flash Point: 657.5°C
• Appearance: /
• Density: 1.575g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.685
• PKA: 4.54±0.10(Predicted)
• CAS DataBase Reference: Uroporphyrinogen III(CAS DataBase Reference)
• NIST Chemistry Reference: Uroporphyrinogen III(1976-85-8)
• EPA Substance Registry System: Uroporphyrinogen III(1976-85-8)

Safety Data

• Hazardous Substances Data: 1976-85-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-27-19(3-7-35(49)50)22(10-38(55)56)30(43-27)15-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)16-31-23(11-39(57)58)18(2-6-34(47)48)26(42-31)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60)

Upstream product

• 487-90-1 porphobilinogen 
• 106-60-5 ALA 
• 18273-06-8 uroporphyrin 
• 75975-56-3 tert-butyl 3,3'-bis<(methoxycarbonyl)methyl>-4,4'-bis<β-(methoxycarbonyl)ethyl>-5'-formyldipyrrylmethane-5-carboxylate 
• 50622-64-5 benzyl 3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-5-methylpyrrole-2-carboxylate 
• 50622-60-1 3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-pyrrole-2-carboxylic acid benzyl ester 
• 75975-60-9 1,4,6-tris<β-(methoxycarbonyl)ethyl>-2,3,5,7-tetrakis<(methoxycarbonyl)methyl>-8-(β-carboxyethyl)-8'-(aminomethyl)bilane lactam 
• 75975-54-1 tert-butyl 3,3'-bis<(methoxycarbonyl)methyl>-4,4'-bis<β-(methoxycarbonyl)ethyl>-5-<(benzyloxy)carbonyl>dipyrrylmethane-5-carboxylate 
• 75993-23-6 tert-butyl 3,3'-bis<(methoxycarbonyl)methyl>-4,4'-bis<β-(methoxycarbonyl)ethyl>-5'-carboxydipyrrylmethane-5-carboxylate 
• 75975-55-2 tert-butyl 3,3'-bis<(methoxycarbonyl)methyl>-4,4'-bis<β-(methoxycarbonyl)ethyl>dipyrrylmethane-5-carboxylate 
• 72423-57-5 5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3methoxycarbonylmethylpyrrole-2-carboxylic acid 
• 72423-67-7 benzyl 2-iodo-3<(methoxycarbonyl)methyl>-4-<β-(methoxycarbonyl)ethyl>-5-pyrrolecarboxylate 
• 75975-52-9 3-(2-Methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 75993-22-5 4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>pyrrole-5-carboxylic acid 

Downstream Products

• 553-12-8 protoporphyrin IX 
• 2624-63-7 coproporphyrinogen III 

Relevant articles and documents

Biosynthesis of corrinoids and porphyrinoids. XI. Source of oxaloacetic acid for uroporphyrinogen III biosynthesis in Arthrobacter hyalinus

The source of oxaloacetic acid, required for the synthesis of porphyrins in Arthrobacter hyalinus, was examined by means of a feeding experiment with [1,3-13C2]glycerol, which is transformed to pyruvic acid. A half of the carbon dioxide liberated from pyruvic acid in the formation of acetyl CoA was utilized for carboxylation of pyruvic acid to generate oxaloacetic acid.

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Synthesis of substrate analogs of methyltransferases in the vitamin B12 biosynthetic pathway and characterization of their enzymatic products

The specificity toward substrate analogs of the first two methyltransferases in the vitamin B12 biosynthetic pathway was probed with 15 synthetic porphyrinogens. Several novel methylated chlorins and isobacteriochlorins were isolated and charac