197643-97-3

Upstream product

• 1310320-95-6 N-acetyl-1-methyl-1-(4-methoxyphenyl)allylamine 
• 2475-92-5 4-methoxyacetophenone oxime 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 177750-10-6 N-(1-(4-methoxy)phenylethyl)acetamide 
• 22927-78-2 5-(4-methoxyphenyl)-5-methyl-2,4-imidazolidinedione 
• 108-24-7 acetic anhydride 

Downstream Products

• 959691-73-7 (R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile 
• 959691-76-0 (R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile 
• 959691-74-8 (S)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile 
• 959691-78-2 (R)-1-(3,4-dichlorophenyl)-3,4-dimethyl-4-(4-hydroxyphenyl)-2-thioxoimidazolidin-5-one 
• 959694-60-1 (R)-2-acetylamino-2-(4-methoxyphenyl)propanoic acid 
• 959694-58-7 methyl (S)-2-amino-2-(4-methoxyphenyl)propionate 
• 959694-59-8 methyl (R)-2-amino-2-(4-methoxyphenyl)propionate 
• 959694-09-8 (R)-4-[2,5-dioxo-4-(4-methoxyphenyl)-4-methylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile 
• 959694-12-3 (R)-4-[2,5-dioxo-4-(4-methoxyphenyl)-4-methylimidazolidin-1-yl]-2-methoxybenzonitrile 
• 959694-61-2 methyl (R)-2-(4-methoxyphenyl)-2-(2-nitrophenyl)sulfonylaminopropionate 
• 959694-62-3 methyl (R)-2-(4-methoxyphenyl)-2-methylaminopropionate 
• 959691-72-6 (R)-1-(3,4-dichlorophenyl)-3,4-dimethyl-4-(4-methoxyphenyl)-2-thioxoimidazolidin-5-one 
• 959694-11-2 (S)-4-[2,5-dioxo-4-(4-methoxyphenyl)-4-methylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile 
• 871842-89-6 (R)-1-carboxy-1-(4-methoxyphenyl)ethyl ammonium hydrochloride 

Relevant academic research and scientific papers

Discovery of diarylhydantoins as new selective androgen receptor modulators

A novel selective androgen receptor modulator scaffold has been discovered through structural modifications of hydantoin antiandrogens. Several 4-(4-hydroxyphenyl)-N-arylhydantoins displayed partial agonism with nanomolar in vitro potency in transactivation experiments using androgen receptor (AR) transfected cells. In a standard castrated male rat model, several compounds showed good anabolic activity on levator ani muscle, dissociated from the androgenic activity on ventral prostate, after oral dosing at 30 mg/kg. (+)-4-[3,4-Dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl] -2-(trifluoromethyl)benzonitrile ((+)-11b) displayed anabolic potency with a strong dissociation between levator ani muscle and ventral prostate (A 50 = 0.5 mg/kg vs 70 mg/kg). The binding modes of two compounds, including (+)-11b, within the AR ligand-binding domain have been studied by cocrystallization experiments using a coactivator-like peptide. Both compounds bound to the same site, and the overall structures of the AR were very similar.

Ruthenium-catalyzed hydrovinylation of N-acetylenamines leading to amines with a quaternary carbon center

A catalytic hydrovinylation of N-acetylenamines with ethylene is reported. This new hydrovinylation reaction is catalyzed by a ruthenium hydride complex, RuHCl(CO)(PCy3)2, providing a series of N-acetylamines with a quaternary carbon center with up to 99% yield.