Benzeneacetic acid, -alpha--(acetylamino)-4-methoxy--alpha--methyl-

Base Information

• Chemical Name: Benzeneacetic acid, -alpha--(acetylamino)-4-methoxy--alpha--methyl-
• CAS No.: 197643-97-3
• Molecular Formula: C12H15 N O4
• Molecular Weight: 237.255
• Mol file: 197643-97-3.mol

Synonyms:Benzeneacetic acid, -alpha--(acetylamino)-4-methoxy--alpha--methyl-

Chemical Property of Benzeneacetic acid, -alpha--(acetylamino)-4-methoxy--alpha--methyl-

Chemical Property:

• PSA: 75.63000
• LogP: 1.52200

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, -alpha--(acetylamino)-4-methoxy--alpha--methyl-

There total 5 articles about Benzeneacetic acid, -alpha--(acetylamino)-4-methoxy--alpha--methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-acetyl-1-methyl-1-(4-methoxyphenyl)allylamine (1310320-95-6) → C12H15NO4 (197643-97-3)

Guidance literature:

With sodium periodate; ruthenium(III) chloride trihydrate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 2h;

DOI:10.1021/ol201142v

Reference yield:

1-(4-methoxyphenyl)ethanone (100-06-1) → C12H15NO4 (197643-97-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride

2.1: iron; acetic acid / toluene / 5 h / 75 °C / Inert atmosphere

3.1: carbonylchlorohydridobis(tricyclohexylphosphine)ruthenium(II); silver trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.33 h / 20 °C / Molecular sieve; Inert atmosphere

3.2: 10 h / 65 °C / 760.05 Torr / Molecular sieve

4.1: sodium periodate; ruthenium(III) chloride trihydrate / tetrachloromethane; water; acetonitrile / 2 h / 20 °C

With sodium periodate; carbonylchlorohydridobis(tricyclohexylphosphine)ruthenium(II); ruthenium(III) chloride trihydrate; hydroxylamine hydrochloride; silver trifluoromethanesulfonate; iron; acetic acid; In tetrachloromethane; water; 1,2-dichloro-ethane; toluene; acetonitrile;

DOI:10.1021/ol201142v

Reference yield:

N-(1-(4-methoxy)phenylethyl)acetamide (177750-10-6) → C12H15NO4 (197643-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: carbonylchlorohydridobis(tricyclohexylphosphine)ruthenium(II); silver trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.33 h / 20 °C / Molecular sieve; Inert atmosphere

1.2: 10 h / 65 °C / 760.05 Torr / Molecular sieve

2.1: sodium periodate; ruthenium(III) chloride trihydrate / tetrachloromethane; water; acetonitrile / 2 h / 20 °C

With sodium periodate; carbonylchlorohydridobis(tricyclohexylphosphine)ruthenium(II); ruthenium(III) chloride trihydrate; silver trifluoromethanesulfonate; In tetrachloromethane; water; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1021/ol201142v

upstream raw materials:

N-acetyl-1-methyl-1-(4-methoxyphenyl)allylamine

4-methoxyacetophenone oxime

1-(4-methoxyphenyl)ethanone

N-(1-(4-methoxy)phenylethyl)acetamide

Downstream raw materials:

(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile

(S)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

(R)-1-(3,4-dichlorophenyl)-3,4-dimethyl-4-(4-hydroxyphenyl)-2-thioxoimidazolidin-5-one