197658-21-2Relevant articles and documents
COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY
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Page/Page column 293, (2020/06/05)
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.
Noble metal-free catalytic decarboxylation of oleic acid to n-heptadecane on nickel-based metal-organic frameworks (MOFs)
Yang,McNichols,Davidson,Schweitzer,Gómez-Gualdrón,Trewyn,Sellinger,Carreon
, p. 3027 - 3035 (2017/08/01)
Nickel based metal organic frameworks (Ni-MOFs) were successfully synthesized using new conjugated carboxylic acid linkers. These conjugated carboxylic acid linkers were synthesized using mild Heck coupling that led to the incorporation of functional groups not possible by traditional synthetic methods. Control of linker size allows for porosity tuning of the crystalline network and high surface area, that, in theory, results in the increased accessibility to Ni metal centers for catalysis. The resultant crystalline Ni-MOFs displayed BET areas as high as ～314 m2 g-1. To investigate their catalytic activity for conversion of oleic acid to liquid hydrocarbons, Ni-MOFs were grown on zeolite 5A beads that served as catalytic supports. The resultant catalysts displayed heptadecane selectivity as high as ～77% at mild reaction conditions, one of the highest yields for non-noble metal containing catalysts. The catalytic activity correlated to the concentration of acid sites. A slight decrease in catalytic activity was observed after catalysts recycling.
Scope and Limitation of the Microwave-Assisted Catalytic Wittig Reaction
Hoffmann, Marcel,Deshmukh, Sunetra,Werner, Thomas
, p. 4532 - 4543 (2015/07/27)
We have developed a microwave-assisted catalytic Wittig reaction. In this paper, we give full account of the scope and limitations of this reaction. A screening of various commercially available phosphine oxides as precatalysts revealed Bu3P=O to be the most promising candidate. We tested 10 silanes for the in situ reduction of the phosphine oxide to generate Bu3P as the actual catalyst. Different epoxides were tested as masked bases. In this context, cyclohexene oxide as well as butylene oxide proved to be suitable. The reaction could be carried out at 125 C, but higher yields and E/Z selectivities were obtained at 150 °C. Under the optimised reaction conditions, more than 40 examples for the conversion of various aldehydes into the corresponding alkenes are reported. The products were obtained in yields of up to 88 with high E selectivities. Moreover, we also describe the further screening of several chiral phosphines as catalysts for the microwave-assisted enantioselective catalytic Wittig reaction. The scope and limitations of the microwave-assisted catalytic Wittig reaction have been evaluated with respect to the catalyst, silane, solvent, reaction conditions, and substrates.
First Microwave-Assisted Catalytic Wittig Reaction
Werner, Thomas,Hoffmann, Marcel,Deshmukh, Sunetra
supporting information, p. 6873 - 6876 (2016/02/19)
We introduce a novel catalytic Wittig reaction based on an inexpensive and readily available phosphane oxide as a precatalyst. The performance of the reaction under microwave irradiation led to significantly improved yields and reaction rates relative to those obtained under conventional heating. Moreover, herein we enclose the first example of the asymmetric catalytic Wittig reaction based on a chiral phosphane as the catalyst.
Templating photodimerization of trans-cinnamic acid esters with a water-soluble Pd nanocage
Karthikeyan,Ramamurthy
, p. 452 - 458 (2007/10/03)
A water-soluble octahedral Pd nanocage acting as a reaction vessel templates the photodimerization of substituted trans-cinnamic acid methyl esters in water. Irradiation of the host-guest complexes of trans-cinnamic acid methyl esters with the Pd nanocage resulted in selective formation of a syn head-head dimer in addition to the corresponding cis isomer. These results suggest that the guest molecules are preoriented in a selective fashion with the hydrophilic ester group facing water and the hydrophobic aryl group tucked within the cavity of the host. Such an orientation occurs at the hydrophobic-hydrophilic interface between the nanocage exterior and interior. Weak intermolecular C-H-π and π-π interactions between the host and the guest(s) are likely to be responsible for the lack of mobility of the reactant olefins during their short excited-state lifetime.
Use of a new hydrophilic phosphine: DPPPA. Rapid and convenient Heck reaction in aqueous medium under microwave irradiation
Villemin,Nechab
, p. 429 - 431 (2007/10/03)
A new water soluble phosphine-ligand: diphenylphosphinyl) phenylphosphonic acid (DPPPA) was used in Heck reaction. The Heck reaction is efficiently and rapidly achieved by a palladium-catalysed reaction in water performed in a Teflon autoclave under microwave irradiation with a commercial microwave oven. The Log P was used for correlating the solubility of the aryl iodide in water with the observed yield.
Palladium complexes supported on hybrid organic-inorganic zirconium phosphite: Selectivity in the Heck reaction
Villemin, Didier,Jaffres, Paul-Alain,Nechab, Belkacem,Courivaud, Frederic
, p. 6581 - 6584 (2007/10/03)
Supported palladium complex on zirconium phosphite-phosphonate was made from triphenylphosphine phosphonic acid. The supported catalyst showed significant selectivity in the competitive Heck reaction between iodobenzene and different iodobenzoates. The re
