19767-93-2Relevant academic research and scientific papers
Facile synthesis of glycol metabolites of phenethylamine drugs
Holshouser,Kolb
, p. 619 - 621 (2007/10/02)
High yields of potential glycol metabolites of p-synephrine, epinephrine, octopamine, and normacromerine can be obtained from the readily available monosubstituted and disubstituted acetophenones. The general procedure involves alpha-bromination followed by displacement with acetate ion and reduction with lithium aluminum hydride. Yields ranged from 46 to 91%. Furthermore, the procedure minimizes some problems inherent in aromatic glycol synthesis which include dimerization and pinacol-pinacolone rearrangement.
