197728-60-2Relevant academic research and scientific papers
Stereoselective Modification of a Cyclopentapeptide via an α-(Ethylthio)glycine Residue
Paulitz, Christian,Steglich, Wolfgang
, p. 8474 - 8478 (2007/10/03)
The solid-phase synthesis of cyclo[Val-D-Gly(SEt)-Pro-Phe-D-Ala] (5) on Kaiser's oxime resin is described. Conversion of 5 to the reactive α-chloroglycine derivative 9 allowed the stereoselective addition of thiols, alcohols, amines and other nucleophiles with formation of the modified cyclopeptides 11a - n.
