19777-08-3

Upstream product

• 16954-69-1 2-methylaminobenzthiazole 
• 98-88-4 benzoyl chloride 
• 95-16-9 1,3-Benzothiazole 
• 88070-48-8 N-methylbenzamide 
• 116928-25-7 benzo[d]thiazol-2-yltriphenylphosphonium trifluoromethanesulfonate 
• 615-20-3 2-chlorobenzo[d][1,3]thiazole 

Downstream Products

• 118215-11-5 N-Benzothiazol-2-yl-N-methyl-thiobenzamide 

Relevant academic research and scientific papers

C-H Functionalization of Benzothiazoles via Thiazol-2-yl-phosphonium Intermediates

Benzothiazoles undergo regioselective C2-H functionalization with triphenylphosphine to form thiazol-2-yl-triphenylphosphonium salts, and these phosphonium salts react with a wide range of O- A nd N-centered nucleophiles to give the corresponding ethers, amines, and C-N biaryls. The reactions proceed under mild conditions and allow for the recovery of triphenylphosphine at the end of the sequence. In the presence of hydroxide, phosphonium salts undergo disproportionation, resulting in the reduction of the benzothiazole, which is useful for specific C2 deuteration of benzothiazoles.

SPECTRAL INVESTIGATIONS OF THE TAUTOMERIC EQUILIBRIA OF THIOACYL DERIVATIVES OF 2-AMINOTHIAZOLE AND 2-AMINOBENZOTHIAZOLE

The positions of the tautomeric equilibria for a number of thioacyl derivatives of 2-aminothiazole and 2-aminobenzothiazole were determined by UV and IR spectroscopy with the use of model compounds.Quantum-chemical calculations by the CNDO/2 method were m