197775-88-5

Upstream product

• 17630-75-0 5-chloro-indolin-2-one 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 301700-24-3 5-chloro-2-phenoxycarbonyloxy-indole-1-carboxylic acid benzyl ester 
• 301700-23-2 5-chloro-2-ethoxycarbonyloxy-indole-1-carboxylic acid benzyl ester 
• 197776-04-8 benzyl 5-chloro-2-oxo-2,3-dihydro-indole-1-carboxylate 

Relevant academic research and scientific papers

TRICYCLIC SPIRO DERIVATIVES AS CRTH2 MODULATORS

The present invention is related to the use of spiro derivatives of Formula (I) for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component. Specifically, the present invention is rel

New routes to oxindole derivatives

A new, practical synthesis of the antirheumatic oxindole derivative, tenidap, has been elaborated. The new approach has initiated studies on the mechanism of the acylation reactions of oxindoles. Methods have been developed for the synthesis of 1-[alkoxy(or aryloxy)carbonyl]- and 1,3-di[alkoxy(or aryloxy)carbonyl]oxindoles starting from oxindoles. The route designed for tenidap has provided a facile access to several analogues, too. On another front, new reaction conditions are described, which turn Wenkert's synthesis of 3-alkyloxindoles (by Raney nickel induced alkylation of oxindoles with alcohols) into a highly efficient synthetic tool. The method has been extended to the synthesis of 3-alkyloxindoles from isatins and to the preparation of 3-(ω-hydroxyalkyl)oxindoles from oxindoles and isatins. Springer-Verlag 2004.

Synthesis of 1,3-di[alkoxy(aryloxy)carbonyl]-2-oxo-2,3-dihydroindoles

Two protocols have been developed for the synthesis of 1,3-di[alkoxy(aryloxy)carbonyl]-2-oxo-2,3-dihydroindoles starting from the corresponding N,O-diacyl derivatives obtained by treatment of 2-oxindoles with chloroformic acid esters and triethylamine. Th