197776-03-7

Basic information

• Product Name: 5-chloro-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole
• Synonyms: 5-chloro-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole
• CAS NO: 197776-03-7
• Molecular Weight: 287.702
• Mol File: 197776-03-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-chloro-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole(197776-03-7)
• EPA Substance Registry System: 5-chloro-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole(197776-03-7)

Safety Data

• Hazardous Substances Data: 197776-03-7(Hazardous Substances Data)

Upstream product

• 1351706-37-0 N-(2-iodo-4-chlorophenyl)-4-methylbenzenesulfonamide 
• 197776-00-4 phenyl 5-chloro-2-[(phenoxycarbonyl)oxy]-1H-indole-1-carboxylate 
• 17630-75-0 5-chloro-indolin-2-one 

Downstream Products

• 120210-48-2 tenidap 
• 255712-72-2 (Z)-5-chloro-3-[1-hydroxy-1-(2-thienyl)methylene]-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole 
• 255712-65-3 5-chloro-1-phenoxycarbonyl-2-(thenoyloxy)indole 
• 255712-76-6 5-chloro-2-methoxycarbonyloxy-indole-1-carboxylic acid phenyl ester 
• 301700-19-6 2-benzyloxycarbonyloxy-5-chloro-indole-1-carboxylic acid phenyl ester 
• 301779-72-6 5-chloro-2-ethoxycarbonyloxy-indole-1-carboxylic acid phenyl ester 

Relevant articles and documents

Synthesis of Oxindoles and Benzofuranones via Oxidation of 2-Heterocyclic BMIDAs

The synthesis of functionalized oxindoles and benzofuranones via oxidation of 2-BMIDA indoles and benzofurans, respectively, is described. Interconversion of boron species (BMIDA→BF3K) was necessary to enable oxidation and overcome boronic acid stability issues associated with a difficult BMIDA hydrolysis. Overall, a robust process was developed that allowed access to a small library of oxindole and benzofuranone products and facilitated the step-efficient synthesis of biologically active compounds containing the oxindole pharmaco-phore.

Synthesis of 1,3-di[alkoxy(aryloxy)carbonyl]-2-oxo-2,3-dihydroindoles

Two protocols have been developed for the synthesis of 1,3-di[alkoxy(aryloxy)carbonyl]-2-oxo-2,3-dihydroindoles starting from the corresponding N,O-diacyl derivatives obtained by treatment of 2-oxindoles with chloroformic acid esters and triethylamine. Th