1978-87-6

Upstream product

• 637-87-6 1-Chloro-4-iodobenzene 
• 455-37-8 3-fluorobenzamide 
• 106-47-8 4-chloro-aniline 
• 1711-07-5 3-fluorobenzoyl chloride 

Downstream Products

• 828264-26-2 ethyl 3'-fluoro-6-chloro-2-phenyl-4-quinolone-3-carboxylate 
• 828264-11-5 2-[(4-chloro-phenylamino)-(3-fluoro-phenyl)-methylene]-malonic acid diethyl ester 
• 1251912-87-4 C₁₃H₇ClFNOS 
• 1186646-43-4 2-(4-chlorophenyl)-5-fluorobenzo[d]isothiazol-3(2H)-one 

Relevant academic research and scientific papers

Studies towards the design and synthesis of novel 1,5-diaryl-1h-imidazole-4-carboxylic acids and 1,5-diaryl-1h-imidazole-4-carbohydrazides as host ledgf/p75 and hiv-1 integrase interaction inhibitors

Two targeted sets of novel 1,5-diaryl-1H-imidazole-4-carboxylic acids 10 and carbohy-drazides 11 were designed and synthesized from their corresponding ester intermediates 17, which were prepared via cycloaddition of ethyl isocyanoacetate 16 and diarylimi

Efficient manganese/copper bimetallic catalyst for N-arylation of amides and sulfonamides under mild conditions in water

An efficient and mild method using a bimetallic MnF2/CuI catalyst at 60 °C in water was developed for the N-arylation of amides and sulfonamides with aryl halides. A variety of functionalized amides and sulfonamides were coupled with different substituted aryl halides to afford the corresponding N-arylated products in good to excellent yields (up to 97 %). An efficient method using a bimetallic MnF2/CuI catalyst in combination with trans-1,2-diaminocyclohexane as the ligand has been developed for the cross-coupling of benzamides and sulfonamides with differently substituted aryl iodides in water. The corresponding N-arylated products were obtained in good to excellent yields (up to 97 %) under the catalytic conditions. Copyright

Role of Hetero-halogen (F · · · X, X = Cl, Br, and I) or homo-halogen (X · · · X, X = F, Cl, Br, and I) interactions in substituted benzanilides

A series of halogen-substituted benzanilides have been synthesized and characterized, and crystallization studies directed toward generation of polymorphs have been performed to delineate the importance of interactions involving halogens. The effect of ha

Synthesis and biological relationships of 3′,6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents

As part of a continuing search for potential anticancer drug candidates in the 2-phenyl-4-quinolone series, 3′,6-substituted 2-phenyl-4-quinolone-3- carboxylic acid derivatives and their salts were synthesized and evaluated. Preliminary screening showed t

Substituted 2-phenyl-4-quinolone-3-carboxylic acid compounds and their use as antitumor agents

Substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives and their salts were synthesized. The results of preliminary screening revealed that these compounds are potent in killing solid tumor cancers.