19780-36-0

Upstream product

• 22286-82-4 2-phenyl-acrylic acid ethyl ester 

Downstream Products

• 122846-52-0 2-Hydroxy-2-phenyl-3-pyrrolidin-1-yl-propionic acid ethyl ester 
• 122846-53-1 2-Hydroxy-2-phenyl-3-piperidin-1-yl-propionic acid ethyl ester 
• 122846-57-5 Ethyl 2-Hydroxy-2-phenyl-3-(4-thiomorpholinyl)-propionate 
• 122846-54-2 2-Hydroxy-2-phenyl-3-piperazin-1-yl-propionic acid ethyl ester 
• 122846-59-7 3-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-2-hydroxy-2-phenyl-propionic acid ethyl ester 
• 122846-69-9 3-(1-azabicyclo[2.2.2]octyl) 2-hydroxy-3-(N,N-bis(2-methoxyethyl)amino)-2-phenylpropionate 
• 122846-67-7 3-(1-azabicyclo[2.2.2]octyl) 2-hydroxy-3-[4-(2,6-dimethylmorpholinyl)]-2-phenylpropionate 
• 122846-64-4 3-(1-azabicyclo[2.2.2]octyl) 2-hydroxy-3-(4-methylpiperazinyl)-2-phenylpropionate 
• 122846-66-6 1-Azabicyclo [2.2.2]octan-3-yl 2-Hydroxy-2-phenyl-3-(4-thiomorpholinyl)propionate 
• 122846-65-5 1-Azabicyclo [2.2.2]octan-3-yl 2-Hydroxy-3-(4-morpholinyl)-2-phenylpropionate 
• 122846-63-3 3-(1-azabicyclo[2.2.2]octyl) 2-hydroxy-2-phenyl-3-piperazinylpropionate 
• 122846-62-2 3-(1-azabicyclo[2.2.2]octyl) 2-hydroxy-2-phenyl-3-piperidinylpropionate 
• 122846-61-1 3-(1-azabicyclo[2.2.2]octyl) 2-hydroxy-2-phenyl-3-pyrrolidynylpropionate 
• 122846-70-2 3-(1-methyl-1-azabicyclo<2.2.2>octyl) 2-hydroxy-3-(4-morpholinyl)-2-phenylpropionate iodide 

Relevant academic research and scientific papers

1-AZABICYCLO[2.2.2]OCTAN-3-YL 2-ARYL-3-AZACYCLO-2-HYDROXYPROPIONATES AND THEIR QUATERNARY SALTS

Novel 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts and their use as antimuscarinic agents having antisecretory activity selective for the gastrointestinal tract are disclosed. The compounds have the formula: STR1 wherein: X=H, halogen, lower alkyl, lower alkoxy, hydroxy, andR=morpholinyl, thiomorpholinyl, piperidinyl, 1,4-dioxa-8-azaspiro[4.5]decanyl, 4-(2,6-dimethylmorpholinyl), 4-ketopiperidinyl, 4-hydroxypiperidinyl, 4-substituted piperazinyl (wherein the substituent is lower alkyl, hydroxyalkyl, acetoxyalkyl, or acyl).Also disclosed are pharmaceutical compositions for treatment of irritable bowel syndrome and methods for using such compounds.

Method of producing L-phenylalanine

There is provided a method of producing L-phenylalanine in high optical purity which comprises treating an N-acylphenylalanine alkyl ester in L form, in the presence of water, with an enzyme capable of hydrolyzing the N-acylphenylalanine alkyl ester in L form to give L-phenylalanine.