122846-65-5

Upstream product

• 122846-56-4 ethyl 2-hydroxy-3-(4-morpholinyl)-2-phenylpropionate 
• 1619-34-7 3-quinuclidinol 
• 19780-36-0 ethyl α-phenylglycidate 

Downstream Products

• 122846-70-2 3-(1-methyl-1-azabicyclo<2.2.2>octyl) 2-hydroxy-3-(4-morpholinyl)-2-phenylpropionate iodide 

Relevant academic research and scientific papers

Synthesis of some 3-(1-azabicyclo[2.2.2]octyl) 3-amino-2-hydroxy-2-phenylpropionates: Profile of antimuscarinic efficacy and selectivity

A series of 3-quinuclidinyl atrolactate [3-(1-azabicyclo[2.2.2]octyl) 2-hydroxy-2-phenylpropionate, QNA] derivatives in which the methyl group of the parent is substituted with a tertiary amino substituent was prepared and tested for antimuscarinic activi

1-AZABICYCLO[2.2.2]OCTAN-3-YL 2-ARYL-3-AZACYCLO-2-HYDROXYPROPIONATES AND THEIR QUATERNARY SALTS

Novel 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts and their use as antimuscarinic agents having antisecretory activity selective for the gastrointestinal tract are disclosed. The compounds have the formula: STR1 wherein: X=H, halogen, lower alkyl, lower alkoxy, hydroxy, andR=morpholinyl, thiomorpholinyl, piperidinyl, 1,4-dioxa-8-azaspiro[4.5]decanyl, 4-(2,6-dimethylmorpholinyl), 4-ketopiperidinyl, 4-hydroxypiperidinyl, 4-substituted piperazinyl (wherein the substituent is lower alkyl, hydroxyalkyl, acetoxyalkyl, or acyl).Also disclosed are pharmaceutical compositions for treatment of irritable bowel syndrome and methods for using such compounds.