197841-22-8Relevant academic research and scientific papers
First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling
Daines, Robert A.,Pendrak, Israil,Sham, Kelvin,Van Aller, Glenn S.,Konstantinidis, Alex K.,Lonsdale, John T.,Janson, Cheryl A.,Qiu, Xiayang,Brandt, Martin,Khandekar, Sanjay S.,Silverman, Carol,Head, Martha S.
, p. 5 - 8 (2003)
The first cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor is reported. The inhibitor was obtained by rational modification of a high throughput screening lead with the aid of a S. pneumoniae FabH homology model. This homology model was used to design analogues that would have both high affinity for the enzyme and appropriate aqueous solubility to facilitate cocrystallization studies.
CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES
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, (2008/06/13)
This invention relates to novel carboxylic acid indole compounds and compositions for use in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
