197861-63-5Relevant academic research and scientific papers
A novel synthesis of sulfone systems as antimicrobial agents
Erian, Ayman W.,Issac, Yvette A.,Sherif, Sherif M.
, p. 127 - 132 (2007/10/03)
The applicability and synthetic potency of novel reagent, 2-aryl-1,1-dicyano-3-(phenylsulfonyl)propenes 3 to develop an expeditious convenient synthetic route of unique polyfunctionally substituted carbocyclic and heterocyclic sulfone systems is reported. Chemical and spectroscopic evidence for the structures of the newly synthesized compounds are described. Some of the obtained compounds were tested for their antimicrobial activity.
1,1-Dicyano-2-phenyl-3-phenylsulphonylpropene: A novel reagent in sulphone chemistry
Erian, Ayman Wahba
, p. 3549 - 3558 (2007/10/03)
1,1-Dicyano-2-phenyl-3-phenylsulphonylpropene could be prepared. This reagent readily reacted with a wide variety of electrophilic reagents to give unique sulphone compounds.
Syntheses with Heterocyclic β-Enaminonitriles: An Expeditious Synthetic Approach to Polyfunctionally Substituted 5-Phenylsulfonylthiophenes and their Fused Derivatives
Sherif,Hussein
, p. 687 - 696 (2007/10/03)
Phenylsulfonylacetophenones 1 react with a mixture of elemental sulfur and malononitrile to yield the corresponding 2-amino-4-aryl-5-phenylsulfonylthiophene-3-carbonitriles 2. Compound 2a could be annelated to the corresponding thieno[2,3-d]pyrimidine and thieno[2,3-c]-pyrazole derivatives 3 and 5 upon reaction with nitrogen nucleophiles (cyanamide and hydroxylamine hydrochloride), respectively. The applicability and synthetic potency of 5 to develop a facile convenient route to the polyfunctionally substituted thieno[2′,3′ : 3, 4]pyrazolo[1,5-a]pyrimidines 8, 14, 17, 20, and 21 is reported. Chemical and spectroscopic evidences for the structures of the new compounds are presented.
