197893-07-5

Basic information

• Product Name: Boc-D-Met-NH2
• Synonyms: Boc-D-Met-NH2;(R)-tert-Butyl (1-amino-4-(methylthio)-1-oxobutan-2-yl)carbamate
• CAS NO: 197893-07-5
• Molecular Formula: C₁₀H₂₀N₂O₃S
• Molecular Weight: 248.3424
• Mol File: 197893-07-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 434.7±40.0 °C(Predicted)
• Appearance: /
• Density: 1.123±0.06 g/cm3(Predicted)
• PKA: 11.15±0.46(Predicted)
• CAS DataBase Reference: Boc-D-Met-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-D-Met-NH2(197893-07-5)
• EPA Substance Registry System: Boc-D-Met-NH2(197893-07-5)

Safety Data

• Hazardous Substances Data: 197893-07-5(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 348-67-4 D-methionine 
• 5241-66-7 (R)-N-(tert-butoxycarbonyl)methionine 

Downstream Products

• 1416467-99-6 4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2R)-1-{4-[(4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl]piperidin-1-yl}-4-(methylsulfanyl)-1-oxobutan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide 
• 1416469-86-7 tert-butyl [(2R)-1-{4-[(4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl]piperidin-1-yl}-4-(methylsulfanyl)-1-oxobutan-2-yl]carbamate 
• 238424-57-2 (2S,3R)-2-(rel-1S-Ethoxycarbonyl-2-methyl-propyl)-3-(2,2,2-trifluoro-acetylamino)-pyrrolidine-1-carboxylic acid benzyl ester 
• 197892-58-3 (R)-2-Ethoxy-3-(2,2,2-trifluoro-acetylamino)-pyrrolidine-1-carboxylic acid benzyl ester 
• 197892-57-2 (R)-2-Oxo-3-(2,2,2-trifluoro-acetylamino)-pyrrolidine-1-carboxylic acid benzyl ester 
• 197893-10-0 (R)-3-tert-Butoxycarbonylamino-2-oxo-pyrrolidine-1-carboxylic acid benzyl ester 
• 197893-08-6 (2-tert-butoxycarbonylamino-4-methylsulfanyl-butyryl)-carbamic acid benzyl ester 
• 1350980-60-7 N-(1-oxyl-4'-demethyl-4-deoxypodophyllic)-D-methine amide 

Relevant articles and documents

Amidation of carboxylic acids via the mixed carbonic carboxylic anhydrides and its application to synthesis of antidepressant (1S,2R)-tranylcypromine

Primary amidations of carboxylic acids 1 or 3 with NH4Cl in the presence of ClCO2Et and Et3N were developed to afford the corresponding primary amides in 22% to quantitative yields. Additionally, we have applied the amidation to the preparation of various amides containing hydroxamic acids and achieved the synthesis of (1S,2R)-tranylcypromine as an antidepressant medicine via Lossen rearrangement.

Carbamates of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis, cytotoxicity and cell cycle effects

In an attempt to generate compounds with superior bioactivity and reduced toxicity, 12 carbamates of 4′-demethyl-4-deoxypodophyllotoxin, N-(1-oxyl-4′-demethyl- 4-deoxypodophyllic)-α-amino acids amides, were synthesized and evaluated for antiproliferative activity and cell cycle effects. These synthesized compounds proved to be more hydrophilic, as well as improved or comparable in vitro cytotoxicities against four cell lines (A-549, HeLa, SiHa, and HL-60) compared with either parent DPT or anti-cancer drug VP-16. Furthermore, flow cytometric analysis exhibited that N-(1-oxyl-4′- demethyl-4-deoxypodophyllic)-d-α-methine amide (15f) induced cell cycle arrest in the G2/M phase in A-549 cells.