197893-52-0

Basic information

• Product Name: ((R)-1-{(S)-2-[(2-Amino-thiazol-4-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethyl)-carbamic acid tert-butyl ester
• CAS NO: 197893-52-0
• Molecular Weight: 549.694
• Mol File: 197893-52-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ((R)-1-{(S)-2-[(2-Amino-thiazol-4-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ((R)-1-{(S)-2-[(2-Amino-thiazol-4-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethyl)-carbamic acid tert-butyl ester(197893-52-0)
• EPA Substance Registry System: ((R)-1-{(S)-2-[(2-Amino-thiazol-4-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethyl)-carbamic acid tert-butyl ester(197893-52-0)

Safety Data

• Hazardous Substances Data: 197893-52-0(Hazardous Substances Data)

Upstream product

• 1028256-60-1 (S)-1-((R)-2-tert-Butoxycarbonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 143060-31-5 N-(tert-butoxycarbonyl)-3,3-diphenyl-D-alanine 
• 138971-65-0 N-(tert-butyloxycarbonyl)-D-3,3-diphenylalanyl-L-proline 

Relevant articles and documents

Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position

A novel class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position has been discovered. Four of these thrombin inhibitors (13b,c,e and 14d) showed nanomolar potency (K(i) 0.8-12 nM), 300-1500-fold selectivity for thrombin compared with trypsin, and good oral bioavailability (F = 40-76%) in rats or dogs. The neutral P1 was expected to increase metabolic stability and oral absorption. Identification of this novel aminopyridyl group at P1 was a key step in our search for a clinical candidate.