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138971-65-0

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138971-65-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 138971-65-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,9,7 and 1 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 138971-65:
(8*1)+(7*3)+(6*8)+(5*9)+(4*7)+(3*1)+(2*6)+(1*5)=170
170 % 10 = 0
So 138971-65-0 is a valid CAS Registry Number.

138971-65-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(tert-butyloxycarbonyl)-D-3,3-diphenylalanyl-L-proline

1.2 Other means of identification

Product number -
Other names N-(tert-butyloxycarbonyl)-D-3,3-diphenylalanyl-L-proline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:138971-65-0 SDS

138971-65-0Relevant articles and documents

Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position

Feng, Dong-Mei,Gardell, Stephen J.,Lewis, S. Dale,Bock, Mark G.,Chen, Zhongguo,Freidinger, Roger M.,Naylor-Olsen, Adel M.,Ramjit, Harri G.,Woltmann, Richard,Baskin, Elizabeth P.,Lynch, Joseph J.,Lucas, Robert,Shafer, Jules A.,Dancheck, Kimberley B.,Chen, I.-Wu,Mao, Shi-Shan,Krueger, Julie A.,Hare, Timothy R.,Mulichak, Anne M.,Vacca, Joseph P.

, p. 3726 - 3733 (2007/10/03)

A novel class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position has been discovered. Four of these thrombin inhibitors (13b,c,e and 14d) showed nanomolar potency (K(i) 0.8-12 nM), 300-1500-fold selectivity for thrombin compared with trypsin, and good oral bioavailability (F = 40-76%) in rats or dogs. The neutral P1 was expected to increase metabolic stability and oral absorption. Identification of this novel aminopyridyl group at P1 was a key step in our search for a clinical candidate.

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