197894-18-1Relevant academic research and scientific papers
Asymmetric synthesis of a xanthine dehydrogenase inhibitor (S)-(-)-BOF-4272 : Mechanism of chiral diaryl sulfoxide formation
Hashimoto, Kinji,Matsugi, Masato,Fukuda, Norio,Kurogi, Yasuhisa
, p. 305 - 315 (2007/10/03)
A pyrazolotriazine derivative (BOF-4272), a potent xanthine dehydrogenase inhibitor, was synthesized in good yield via 9 steps from vanillin. The asymmetric synthesis was achieved effectively by a modified Oae's asymmetric oxidation of diaryl sulfide. A m
