197896-26-7Relevant academic research and scientific papers
Synthesis of anti-tumour phosphatidylinositol analogues from glucose by the use of ring-closing olefin metathesis
Andresen, Thomas L.,Skytte, Dorthe M.,Madsen, Robert
, p. 2951 - 2957 (2007/10/03)
A divergent strategy is described for synthesis of the novel phosphatidylinositols 1-3. The synthetic approach commences from benzyl-protected methyl 6-iodo-6-deoxy-α-D-glucopyranoside, which undergoes zinc-mediated reductive fragmentation followed by vin
AKT INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
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Page 12, (2010/02/06)
Disclosed are inhibitors of the serine/threonine kinase Akt, pharmaceutical compositions comprising such inhibitors, and a method of preventing or treating a disease or condition in an animal by the use of such inhibitors. The Akt inhibitors have the form
Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt
Kozikowski, Alan P.,Sun, Haiying,Brognard, John,Dennis, Phillip A.
, p. 1144 - 1145 (2007/10/03)
The synthesis from l-quebrachitol of a series of 3-deoxygenated ether lipid-type phosphatidylinositol (PI) analogues is reported, that selectively block activation of Akt and downstream substrates without affecting activation of the upstream kinase, PDK-1
Synthesis of 1D-3-deoxy- and -2,3-dideoxyphosphatidylinositol
Kozikowski, Alan P.,Qiao, Lixin,Tueckmantel, Werner,Powis, Garth
, p. 14903 - 14914 (2007/10/03)
Both 1D-3-deoxy- and -2,3-dideoxyphosphatidylinositol (3 and 18) were synthesized using the regioisomeric mixture of viburnitol 1,2:4,5- and 1,2:5,6- diacetonides as starting material. Selective acidic hydrolysis and subsequent benzylation or deoxygenatio
