701976-55-8 Usage
Uses
Used in Cancer Therapy:
SH-6 is used as an anticancer agent for its potential to inhibit cancer cell growth and metastasis by blocking the activity of sphingosine kinase.
Used in Inflammatory Disease Treatment:
SH-6 is used as an anti-inflammatory agent for its potential to reduce inflammation in diseases such as arthritis and inflammatory bowel disease by inhibiting the activity of sphingosine kinase.
Used in Neuroprotection:
SH-6 is used as a neuroprotective agent for its potential ability to protect against oxidative stress and apoptosis in the central nervous system by blocking the activity of sphingosine kinase.
Check Digit Verification of cas no
The CAS Registry Mumber 701976-55-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,0,1,9,7 and 6 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 701976-55:
(8*7)+(7*0)+(6*1)+(5*9)+(4*7)+(3*6)+(2*5)+(1*5)=168
168 % 10 = 8
So 701976-55-8 is a valid CAS Registry Number.
701976-55-8Relevant academic research and scientific papers
Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt
Kozikowski, Alan P.,Sun, Haiying,Brognard, John,Dennis, Phillip A.
, p. 1144 - 1145 (2007/10/03)
The synthesis from l-quebrachitol of a series of 3-deoxygenated ether lipid-type phosphatidylinositol (PI) analogues is reported, that selectively block activation of Akt and downstream substrates without affecting activation of the upstream kinase, PDK-1
