1979-52-8

Basic information

• Product Name: Benzene, 1-[2,2-difluoro-1-(trifluoromethyl)ethenyl]-4-methyl-
• CAS NO: 1979-52-8
• Molecular Formula: C10H7F5
• Molecular Weight: 222.158
• Mol File: 1979-52-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 1-[2,2-difluoro-1-(trifluoromethyl)ethenyl]-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-[2,2-difluoro-1-(trifluoromethyl)ethenyl]-4-methyl-(1979-52-8)
• EPA Substance Registry System: Benzene, 1-[2,2-difluoro-1-(trifluoromethyl)ethenyl]-4-methyl-(1979-52-8)

Safety Data

• Hazardous Substances Data: 1979-52-8(Hazardous Substances Data)

Upstream product

• 36029-90-0 p-Methyl-α-(chlordifluormethyl)-α-(trifluormethyl)-benzylchlorid 
• 394-59-2 2,2,2-trifluoro-1-(p-tolyl)ethanone 
• 115262-00-5 [chloro(difluoro)methyl]trimethylsilane 
• 36029-81-9 p-Methyl-α-(chlordifluormethyl)-α-(trifluormethyl)-benzylalkohol 
• 431-49-2 2-bromo-1,1,3,3,3-pentafluoropropene 
• 624-31-7 4-tolyl iodide 
• 1895-39-2 sodium chlorodifluoroacetate 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 108-88-3 toluene 

Downstream Products

• 2396-26-1 1-methyl-4-(perfluoropropan-2-yl)benzene 
• 35462-71-6 1-(1,1,1,3,3,3-hexafluoropropan-2-yl)-4-methylbenzene 
• 36029-74-0 1-Trifluormethyl-1-p-tolyl-2,2-diphenylethylen 

Relevant articles and documents

An I(I)/I(III) Catalysis Route to the Heptafluoroisopropyl Group: A Privileged Module in Contemporary Agrochemistry

The heptafluoroisopropyl group is emerging as a privileged chemotype in contemporary agrochemistry and features prominently in the current portfolio of leading insecticides. To reconcile the expansive potential of this module with the synthetic challenges

CARBOCYCLIC SULFONE RORγ MODULATORS

Described are RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.

Preparation of β,β-Difluoro-α-(trifluoromethyl)styrenes by Palladium-Catalyzed Coupling of Aryl Iodides with Pentafluoropropen-2-ylzinc Reagent

Substituted aromatic iodides are functionalized by pentafluoropropen-2-ylzinc, CF3C(ZnX)=CF2 (X = Br, I, or CF2=CCF3-), in the presence of Pd(PPh3)4 to give the corresponding arenes in good yields.This is particularly attractive for the preparation of title styrenes substituted with groups such as -NO2 or CO2R, which are incompatible with organomagnesium reagents.The best yields of the title styrenes with electron-donating substituents were obtained in DMF.For electron-withdrawing substituents, the best results were achieved in triglyme.A correlation was observed between Hammett ? constants and 19F NMR chemical shifts (R = 0.93-0.99, n = 8) and 2JF-F coupling constants (R = 0.94, n = 8).