197906-11-9

Upstream product

• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 105-53-3 diethyl malonate 
• 637-69-4 4-Methoxystyrene 

Downstream Products

• 471294-63-0 4-(4-methoxy-phenyl)-2-oxo-3-(3,4,5-trimethoxy-phenyl)-cyclopent-3-ene-1,1-dicarboxylic acid diethyl ester 
• 471294-69-6 toluene-4-sulfonic acid 3-(4-methoxy-phenyl)-2-(3,4,5-trimethoxy-phenyl)-cyclopent-2-enyl ester 
• 471294-68-5 3-(4-methoxy-phenyl)-2-(3,4,5-trimethoxy-phenyl)-cyclopent-2-enol 
• 471294-66-3 3-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)cyclopent-2-en-1-one 
• 471294-59-4 2-[2-(4-Methoxy-phenyl)-2-oxo-ethyl]-2-[2-(3,4,5-trimethoxy-phenyl)-acetyl]-malonic acid diethyl ester 

Relevant academic research and scientific papers

Cu(OAc)2-Triggered Cascade Reaction of Malonate-Tethered Acyl Oximes with Indoles, Indole-2-alcohols, and Indole-2-carboxamides

A Cu(OAc)2-promoted cascade reaction of malonate-tetherd acyl oximes with indoles, indole-2-alcohols, or indole-2-carboxmides provides facile access to polysubstituted 3-pyrrolin-2-ones. The reaction features the generation of two adjacent elec

TBAI/TBHP-Promoted Generation of Malonyl Radicals: Oxidative Coupling with Styrenes Leads to γ-Keto Diesters

A metal-free protocol for oxidative coupling of malonic esters with styrenes to form γ-keto diesters has been developed. Key to the success of this process is the generation of malonyl radicals from unfunctionalized malonic esters under organo-catalysis conditions with TBAI and TBHP. This process tolerates both terminal and internal olefins with diverse malonic esters. It provides a new green metal-free alternative to traditional metal mediated process for generation of malonyl radicals and there by γ-keto diesters.

Synthesis and anti-tumor activity of novel combretastatins: Combretocyclopentenones and related analogues

A series of 2-(3,4,5-trimethoxyphenyl)-3-arylcyclopent-2-ene-1-ones (8a-8e) and their related analogues, including pentenone 9a, pentenol 10a, pentene 12a, and furane 15, were synthesized and evaluated for cytotoxicity against murine and human tumor cell lines. Compounds 8a-c, 8e and 9a showed strong cytotoxicity with IC50 values in the range of 8-34 ng/mL. Compound 8e exhibited significant anti-tumor activity in BDF1 mice bearing Lewis lung carcinoma cells with an inhibition ratio of 59%.

1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses

Compounds of formula (I) and (II): STR1 ?wherein R is hydrogen, halogen or alkyl; R1 is alkyl, amino or substituted amino; R2 is optionally substituted phenyl; R3 is hydrogen, halogen or optionally substituted alkyl; R4 is hydrogen, optionally substituted alkyl, cycloalkyl, aryl, or aralkyl! have valuable analgesic, anti-inflammatory, anti-pyretic and anti-allergic activities and have the ability to inhibit the production of leukotrienes and to inhibit bone resorption. They are relatively free from the side effects which generally result from the administration of compounds having these kinds of activities.