197963-31-8

Upstream product

• 197963-30-7 methyl N-(2,2-dimethyl-5-phenylpent-4-ynyl)glycinate 
• 197963-29-4 2,2-dimethyl-5-phenylpent-4-ynal 
• 3355-31-5 1-chloro-3-phenyl-2-propyne 

Downstream Products

• 197963-32-9 ethyl 2-(2,2-dimethyl-6-hydroxy-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-oxoacetate 
• 226900-28-3 2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-6-yl trifluoromethanesulfonate 
• 226900-31-8 N,N-diethyl 2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-6-yl carbamate 
• 156897-06-2 licofelone 
• 133111-56-5 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine 
• 156897-35-7 ethyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)acetate 
• 197963-34-1 ethyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-oxoacetate 
• 197963-33-0 ethyl 2-(2,2-dimethyl-7-phenyl-6-trifluoromethanesulfonyloxy-2,3-dihydro-1H-pyrrolizin-5-yl)-2-oxoacetate 
• 226900-35-2 diethyl 2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-6-yl phosphate 

Relevant academic research and scientific papers

A Thermal Bicyclization: Synthesis of Substituted 2,3,5,6-Tetrahydro-6-oxo-1H-pyrrolizines

2,3,5,6-Tetrahydro-6-oxo-1H-pyrrolizines, which are potential precursors of 2,3-dihydro-1H-pyrrolizines, were synthesized by a smooth thermal acid-promoted bicyclization of ω-acetylenic aminoesters.

Synthetic studies towards ML-3000: A concise synthesis of this non- steroidal anti-inflammatory drug

ML-3000 was obtained from 1-chloro-3-phenyl-2-propyne in 8 steps with an overall yield of 19%. The key steps are a thermal acid-promoted bicyclization of an ω-acetylenic amino ester and a Suzuki cross-coupling reaction between a heteroaryl triflate and (4-chlorophenyl)boronic acid.