197971-40-7Relevant academic research and scientific papers
Synthesis and biochemical studies of phosphorus-based "tetrahedral mimics" as inhibitors of ATP-dependent ligases
Coward, James K.
, p. 113 - 116 (2007/10/03)
The synthesis of several phosphapeptides and the biochemical evaluation of these compounds as inhibitors of glutathionylspermidine synthetase and folylpolyglutamate synthetase is described.
Design, synthesis, and biochemical evaluation of phosphonate and phosphonamidate analogs of glutathionylspermidine as inhibitors of glutathionylspermidine synthetase/amidase from Escherichia coli
Chen, Shoujun,Lin, Chun-Hung,Kwon, David S.,Walsh, Christopher T.,Coward, James K.
, p. 3842 - 3850 (2007/10/03)
Three phosphapeptides designed to mimic two distinct tetrahedral intermediates formed during either the synthesis or hydrolysis of glutathionylspermidine (Gsp) were synthesized and evaluated as inhibitors of the bifunctional enzyme Gsp synthetase/amidase.
