(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid benzyl ester 3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propyl ester

Base Information

Chemical Name:(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid benzyl ester 3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propyl ester
CAS No.:197971-40-7
Molecular Formula:C₃₉H₄₂N₃O₉P
Molecular Weight:727.751
Hs Code.:

(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid benzyl ester 3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propyl ester

Synonyms:(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid benzyl ester 3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propyl ester

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Chemical Property of (1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid benzyl ester 3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propyl ester

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Technology Process of (1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid benzyl ester 3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propyl ester

There total 8 articles about (1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid benzyl ester 3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33512-26-4
diethyl (phthalimidomethyl)phosphonate

: 197971-40-7
(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid benzyl ester 3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / 1.) TMSBr, 2.) AcOH / CH₂Cl₂ / 12 h / Ambient temperature

2: 1.) thionyl chloride / 1.) DMF, -35 deg C, 30 min, 2.) DMF, a) 0 deg C, 1 h, b) RT, 12 h

3: oxalyl chloride / CH₂Cl₂ / 2 h / Ambient temperature

4: DMAP / CH₂Cl₂ / Ambient temperature

With dmap; thionyl chloride; oxalyl dichloride; trimethylsilyl bromide; acetic acid; In dichloromethane;
DOI:10.1021/jm970414b

Reference yield:

: 49594-18-5
(phthalimidomethyl) phosphonic acid

: 197971-40-7
(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid benzyl ester 3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) thionyl chloride / 1.) DMF, -35 deg C, 30 min, 2.) DMF, a) 0 deg C, 1 h, b) RT, 12 h

2: oxalyl chloride / CH₂Cl₂ / 2 h / Ambient temperature

3: DMAP / CH₂Cl₂ / Ambient temperature

With dmap; thionyl chloride; oxalyl dichloride; In dichloromethane;
DOI:10.1021/jm970414b

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 197971-40-7
(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid benzyl ester 3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N, DMAP / CH₂Cl₂ / 24 h / Ambient temperature

2: 81 percent / TBAF, AcOH / tetrahydrofuran / 6 h / Ambient temperature

3: DMAP / CH₂Cl₂ / Ambient temperature

With dmap; tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm970414b