198019-17-9Relevant academic research and scientific papers
Preparation and reactions of (β-trifluoromethyl)vinyl sulfonium salt
Maeda, Ryoko,Ooyama, Kyoko,Anno, Ryoko,Shiosaki, Masahiro,Azema, Takayuki,Hanamoto, Takeshi
supporting information; experimental part, p. 2548 - 2550 (2010/07/20)
(β-Trifluoromethyl)vinyl sulfonium salt as a novel three-carbon fluorinated building block was conveniently prepared from easily available (β-trifluoromethyl)vinyl sulfide and diphenyl iodonium salt in excellent yield. This easily handled crystalline reag
Intramolecular S(N)2 reaction at α-carbon of trifluoromethyl group: Preparation of optically active 2-trifluoromethylaziridine
Katagiri, Toshimasa,Ihara, Hideki,Takahashi, Mikihiro,Kashino, Setsuo,Furuhashi, Keizo,Uneyama, Kenji
, p. 2933 - 2937 (2007/10/03)
We have succeeded in intramolecular nucleophilic substitution of the hydroxyl group in (S)-1-(alkylamino)-3,3,3-trifluoro-2-propanol. The reaction provides an optically pure (R)-1-benzyl-2-trifluoromethylaziridine in good yield from optically pure (S)-3-(benzylamino)-1,1,1-trifluoro-2-propanol which was prepared from (S)-3,3,3-trifluoropropene oxide (75% ee).
