19808-30-1

Basic information

• Product Name: 5-bromo-1H-pyrimidin-4-one
• Synonyms: 5-bromo-1H-pyrimidin-4-one;5-Bromo-4-Pyrimidone;5-BROMOPYRIMIDIN-4(1H)-ONE;5-Bromo-3,4-dihydropyrimidine-4-one;5-Bromo-4(1H)-pyrimidinone;5-Bromopyrimidine-4(3H)-one;4(1H)-Pyrimidinone, 5-bromo-;4(3H)-Pyrimidinone, 5-bromo-
• CAS NO: 19808-30-1
• Molecular Formula: C₄H₃BrN₂O
• Molecular Weight: 174.98342
• EINECS: 243-334-4
• Mol File: 19808-30-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 198-200℃
• Boiling Point: 241 °C at 760 mmHg
• Flash Point: 99.5 °C
• Appearance: /
• Density: 2 g/cm³
• Vapor Pressure: 0.0237mmHg at 25°C
• Refractive Index: 1.678
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 7.25±0.40(Predicted)
• CAS DataBase Reference: 5-bromo-1H-pyrimidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-1H-pyrimidin-4-one(19808-30-1)
• EPA Substance Registry System: 5-bromo-1H-pyrimidin-4-one(19808-30-1)

Safety Data

• TSCA: Yes
• Hazardous Substances Data: 19808-30-1(Hazardous Substances Data)

Usage

General Description

5-bromo-1H-pyrimidin-4-one, also known as 5-bromo-4(1H)-pyrimidinone, is a chemical compound with the molecular formula C4H3BrN2O. It is an organic heterocyclic compound consisting of a pyrimidine ring with a bromine atom and a carbonyl group attached to it. 5-bromo-1H-pyrimidin-4-one is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in the production of DNA-intercalating agents and fluorescent dyes. Additionally, 5-bromo-1H-pyrimidin-4-one has potential applications in the field of medicinal chemistry and drug discovery due to its structural features and reactivity.

InChI:InChI=1/C4H3BrN2O/c5-3-1-6-2-7-4(3)8/h1-2H,(H,6,7,8)

Upstream product

• 51953-18-5 pyrimidine-4(3H)-one 
• 4595-59-9 5-bromopyrimidine 
• 4319-85-1 5-bromo-4-methoxy-pyrimidine 
• 51953-17-4 Pyrimidin-4-ol 

Downstream Products

• 56181-39-6 4-chloro-5-bromopyrimidine 
• 1232361-96-4 4-(benzyloxy)-5-bromopyrimidine 
• 4319-85-1 5-bromo-4-methoxy-pyrimidine 
• 936635-88-0 5-bromo-3-(4-methoxybenzyl)pyrimidin-4(3H)-one 
• 14248-02-3 5-bromo-3-methyl-4-pyrimidone 
• 543726-87-0 5-bromo-3-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-3H-pyrimidin-4-one 

Relevant articles and documents

PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS

Compounds of the general formula(I): (I) processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

IMIDAZOPYRROLIDINONE COMPOUNDS

The invention relates to compounds of formula (I): (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.

SUBSTITUTED 5-(PYRAZIN-2-YL)-1H-PYRAZOLO [3,4-B] PYRIDINE AND PYRAZOLO [3,4-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3,4-b] pyridine, 5-(pyrazin-2-yl)-1H-pyrrolo[2,3-b]pyridine and pyrazolo [3,4-b] pyridine derivatives according to formula I, II and VII, and methods for making same, which are inhibitors of constitutively activated Tyrosine Kinase-Like (TKL), CMGC protein kinases family members and can be useful in the treatment of Parkinson?s disease, Alzheimer?s disease, Down?s Syndrome, Huntington?s disease, other neurodegenerative and central nervous system disorders, cancer, metabolic disorders and inflammatory diseases. Also disclosed are pharmaceutical compositions including the compounds and methods of inhibiting wild type and/or mutated protein kinase activities of these families and the treatment of disorders associated there with using compounds and pharmaceutical compositions including the compounds.