19811-25-7

Basic information

• Product Name: methyl 2-((4-methoxybenzyl)oxy)-2-methylpropanoate
• Synonyms: methyl 2-((4-methoxybenzyl)oxy)-2-methylpropanoate
• CAS NO: 19811-25-7
• Molecular Weight: 238.284
• Mol File: 19811-25-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 2-((4-methoxybenzyl)oxy)-2-methylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-((4-methoxybenzyl)oxy)-2-methylpropanoate(19811-25-7)
• EPA Substance Registry System: methyl 2-((4-methoxybenzyl)oxy)-2-methylpropanoate(19811-25-7)

Safety Data

• Hazardous Substances Data: 19811-25-7(Hazardous Substances Data)

Upstream product

• 2110-78-3 methyl 2-hydroxy-2-methylpropionate 
• 824-94-2 p-methoxybenzyl chloride 

Relevant articles and documents

A Unified Strategy for the Asymmetric Synthesis of Highly Substituted 1,2-Amino Alcohols Leading to Highly Substituted Bisoxazoline Ligands

A general procedure for the asymmetric synthesis of highly substituted 1,2-amino alcohols in high yield and diastereoselectivity is described that uses organometallic additions of a wide range of nucleophiles to tert-butylsulfinimines as the key step. The addition of organolithium reagents to these imines follows a modified Davis model. The diastereoselectivity for this reaction depends significantly on both the nucleophile and electrophile. These highly substituted 1,2-amino alcohols are used to synthesize stereochemically diverse and structurally novel, polysubstituted 2,2′-methylene(bisoxazoline) ligands in high yields.

PHENYL ACETAMIDE DERIVATIVE

[Problems] To provide a compound which is useful as a GK activator. [Means for Solving Problems] The present inventors have conducted extensive studies on a phenylacetamide derivative, and as a result, have confirmed that a phenylacetamide derivative having sulfonyl group and cycloalkyl group on the phenyl group and having heteroaryl group on the nitrogen atom in the amide has an excellent GK activation action, thereby completing the present invention. The compound of the present invention is useful as an agent for treating diabetes, in particular, type II diabetes, since it has an excellent GK activation action.