19815-97-5 Usage
General Description
2-BROMO-1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-1-ETHANONE is a chemical compound with the formula C10H9BrO3. It is a highly reactive and versatile compound that is commonly used in organic synthesis and medicinal chemistry. The presence of a bromine atom and a benzodioxin moiety in its structure makes it an important building block for various pharmaceutical and agrochemical products. It is also used as an intermediate in the synthesis of other organic compounds and is known for its potential biological activities, making it an important molecule in drug discovery and development. However, it is important to handle and use this chemical with caution due to its reactivity and potential health hazards.
Check Digit Verification of cas no
The CAS Registry Mumber 19815-97-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,8,1 and 5 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 19815-97:
(7*1)+(6*9)+(5*8)+(4*1)+(3*5)+(2*9)+(1*7)=145
145 % 10 = 5
So 19815-97-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H9BrO3/c11-6-8(12)7-2-1-3-9-10(7)14-5-4-13-9/h1-3H,4-6H2
19815-97-5Relevant articles and documents
Synthesis and biological evaluation of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives as novel potent transforming growth factor-β type 1 receptor inhibitors
Chang, Shaohua,Guo, Zhuang,Li, Xue,Sun, Tianwen,Wang, Hai,Wang, Xiaowei,Wang, Yazhou,Xu, Guofeng,Xu, Tianwei,Yu, Wenying,Yu, Zhuangzhuang,Zhang, Yan,Zhao, Liwen
, (2020/05/08)
Inhibition of transforming growth factor β (TGF-β) type 1 receptor (ALK5) provides a feasible approach for the treatment of fibrotic diseases and malignant tumors. In this study, we designed and synthesized a new series of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives, and evaluated biologically as TGF-β type 1 receptor inhibitors. The most potent compound 15r inhibited the ALK5 enzyme and NIH3T3 cell viability with IC50 values of 44 and 42.5 nM, respectively. Compound 15r also displayed better oral plasma exposure and excellent bioavailability than LY-3200882, and in vivo inhibited 65.7% of the tumor growth in a CT26 xenograft mouse model.