29668-43-7

Basic information

• Product Name: 2,3-DIHYDRO-1,4-BENZODIOXINE-5-CARBALDEHYDE
• Synonyms: 2,3-dihydro-1,4-benzodioxine-5-carbaldehydel;methyl 2,3-dihydrobenzo[b][1,4]dioxine-5-carbaldehyde;1,4-Benzodioxin-5-carboxaldehyde, 2,3-dihydro-;2,3-DIHYDRO-1,4-BENZODIOXINE-5-CARBALDEHYD;1,4-BENZODIOXANE-5-CARBOXALDEHYDE;2,3-DIHYDRO-1,4-BENZODIOXINE-5-CARBALDEHYDE;1,4-Benzodioxan-5-carboxaldehyde
• CAS NO: 29668-43-7
• Molecular Formula: C₉H₈O₃
• Molecular Weight: 164.16
• Mol File: 29668-43-7.mol
• Article Data: 16

Chemical Properties

• Melting Point: 62 °C
• Boiling Point: 116.1 °C
• Flash Point: 116.1 °C
• Appearance: /
• Density: 1.262 g/cm³
• Vapor Pressure: 0.00313mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,3-DIHYDRO-1,4-BENZODIOXINE-5-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO-1,4-BENZODIOXINE-5-CARBALDEHYDE(29668-43-7)
• EPA Substance Registry System: 2,3-DIHYDRO-1,4-BENZODIOXINE-5-CARBALDEHYDE(29668-43-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36-52
• Safety Statements: 26
• Hazardous Substances Data: 29668-43-7(Hazardous Substances Data)

Usage

General Description

2,3-Dihydro-1,4-benzodioxine-5-carbaldehyde is a chemical compound with the molecular formula C9H8O3. It is a white solid with a floral, sweet, and powdery odor. 2,3-DIHYDRO-1,4-BENZODIOXINE-5-CARBALDEHYDE is commonly used in the synthesis of various pharmaceuticals and organic compounds. It is also used in the production of perfumes, flavorings, and other aromatic products. Additionally, it has potential applications in agrochemicals and as a precursor for the synthesis of other organic compounds. 2,3-Dihydro-1,4-benzodioxine-5-carbaldehyde is an important building block in organic synthesis and is used in various research and industrial applications.

InChI:InChI=1/C9H8O3/c10-6-7-2-1-3-8-9(7)12-5-4-11-8/h1-3,6H,4-5H2

Upstream product

• 24677-78-9 2,3-dihydroxybenzaldehyde 
• 274910-19-9 (2,3-dihydrobenzo[b][1,4]dioxin-5-yl)methanol 
• 106-93-4 ethylene dibromide 
• 624-73-7 1,2-Diiodoethane 

Downstream Products

• 860653-20-9 [2-(allylamino)-5-chlorophenyl](2,3-dihydro-1,4-benzodioxin-5-yl)methanol 
• 880782-74-1 (2,3-dihydro-benzo[1,4]dioxin-5-yl)-(1-trityl-1H-imidazol-4-yl)-methanol 
• 19815-97-5 2-bromo-1-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)ethanone 
• 274910-20-2 2-(2,3-dihydro-1,4-benzodioxin-5-yl)acetic acid 
• 116939-11-8 monochlormethylbenzo-1,4-dioxane 
• 1311515-42-0 C₁₇H₂₁NO₆ 
• 158504-37-1 methyl 8-amino-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylate 
• 214894-91-4 2,3-dihydro-benzo[1,4]dioxine-5-carboxylic acid methyl ester 
• 4442-53-9 2,3-dihydro-1,4-benzodioxine-5-carboxylic acid 
• 1312470-11-3 C₂₁H₁₉NO₃ 
• 937056-03-6 benzyl 2-[8-chloro-6-(2,3-dihydro-1,4-benzodioxin-5-yl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate 
• 937058-15-6 benzyl (E)-3-(1-{4-chloro-2-[2,3-dihydro-1,4-benzodioxin-5-yl(hydroxy)methyl]phenyl}-1H-pyrrol-2-yl)-2-propenoate 

Relevant articles and documents

3-(5-METHOXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of formula (I') and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

2-Phenylcyclopropylmethylamine Derivatives as Dopamine D2Receptor Partial Agonists: Design, Synthesis, and Biological Evaluation

Partial agonist activity at the dopamine D2 receptor (D2R) is the primary pharmacological feature of the third-generation antipsychotics─aripiprazole, brexpiprazole, and cariprazine. However, all these drugs share a common phenyl-piperazine moiety as the primary pharmacophore. In this study, we designed and synthesized a series of novel compounds based on the 2-phenylcyclopropylmethylamine (PCPMA) scaffold and studied their pharmacological activity at the D2R. A number of potent D2R partial agonists were identified through binding affinity screening and functional activity profiling in both G protein and β-arrestin assays. The structure-functional activity relationship results showed that the spacer group is crucial for fine-tuning the intrinsic activity of these compounds. Compounds (+)-14j and (+)-14l showed good pharmacokinetic properties and an unexpected selectivity against the serotonin 2A (5-HT2A) receptor. Preliminary suppressive effects in a mouse hyperlocomotion model proved that these PCPMA-derived D2R partial agonists are effective as potential novel antipsychotics.

Heterocyclic compound

The present invention relates to compound (I) or a salt thereof which has a ROR γ t inhibitory action. wherein each symbol is as defined in the specification.