1983-12-6Relevant academic research and scientific papers
A Trifluoromethylcarbene Source
Duan, Yaya,Lin, Jin-Hong,Xiao, Ji-Chang,Gu, Yu-Cheng
, p. 2471 - 2474 (2016)
The trifluoromethylcarbene (:CHCF3) was found to be conveniently generated from (2,2,2-trifluoroethyl)diphenyl-sulfonium triflate (Ph2S+CH2CF3 -OTf), which was successfully applied in Fe-catalyzed cyclopropanation of olefins, giving the corresponding trifluoromethylated cyclopropanes in high yields.
Iodotrifluoromethylation of alkenes and alkynes with sodium trifluoromethanesulfinate and iodine pentoxide
Hang, Zhaojia,Li, Zejiang,Liu, Zhong-Quan
supporting information, p. 3648 - 3651 (2014/08/05)
A scalable, selective, and operationally easy iodotrifluoromethylation of a wide range of alkenes and alkynes by using two simple and safe solids, sodium trifluoromethanesulfinate and iodine pentoxide, in aqueous medium has been developed. Mechanistic studies confirm that free-radical processes are involved in this system since the key radical intermediates such as CF3 and β-CF3 alkyl radicals have been clearly detected by spin trapping and electron spin resonance.
