198421-68-0

Basic information

• Product Name: N²-[4-tert-butyloxy-3S-(4-cyanophenylthio)-2S-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide
• Synonyms: N²-[4-tert-butyloxy-3S-(4-cyanophenylthio)-2S-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide
• CAS NO: 198421-68-0
• Molecular Weight: 489.679
• Mol File: 198421-68-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N²-[4-tert-butyloxy-3S-(4-cyanophenylthio)-2S-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N²-[4-tert-butyloxy-3S-(4-cyanophenylthio)-2S-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide(198421-68-0)
• EPA Substance Registry System: N²-[4-tert-butyloxy-3S-(4-cyanophenylthio)-2S-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide(198421-68-0)

Safety Data

• Hazardous Substances Data: 198421-68-0(Hazardous Substances Data)

Upstream product

• 112245-04-2 (R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid 
• 6339-51-1 bis(4-cyanophenyl)disulfane 
• 89226-12-0 (S)-2-amino-N,3,3-trimethylbutanamide 
• 198421-66-8 3S-(4-cyanophenylthio)-2S-isobutylbutan-1,4-dioic acid 4-tert-butyl ester 

Downstream Products

• 252670-72-7 N²-[3S-(4-cyanophenylthio)-4-hydroxy-2S-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide 

Relevant articles and documents

New α-substituted succinate-based hydroxamic acids as TNFα convertase inhibitors

Tumor necrosis factor α convertase (TACE), the enzyme responsible for the processing of proTNFα to TNFα, has been reported to be a metalloproteinase closely related to matrix metalloproteinases (MMPs). Current inhibitors of TACE such as succinate-based hy