N²-[4-tert-butyloxy-3S-(4-cyanophenylthio)-2S-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide

Base Information

• Chemical Name: N²-[4-tert-butyloxy-3S-(4-cyanophenylthio)-2S-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide
• CAS No.: 198421-68-0
• Molecular Formula: C₂₆H₃₉N₃O₄S
• Molecular Weight: 489.679

Synonyms:N²-[4-tert-butyloxy-3S-(4-cyanophenylthio)-2S-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide

Chemical Property of N²-[4-tert-butyloxy-3S-(4-cyanophenylthio)-2S-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-[4-tert-butyloxy-3S-(4-cyanophenylthio)-2S-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide

There total 3 articles about N²-[4-tert-butyloxy-3S-(4-cyanophenylthio)-2S-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(S)-2-amino-N,3,3-trimethylbutanamide (89226-12-0) + 3S-(4-cyanophenylthio)-2S-isobutylbutan-1,4-dioic acid 4-tert-butyl ester (198421-66-8) → N2-[4-tert-butyloxy-3S-(4-cyanophenylthio)-2S-isobutylsuccinyl]-L-tert-leucine-N1-methylamide (198421-68-0)

Guidance literature:

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm990377j

Reference yield:

bis(4-cyanophenyl)disulfane (6339-51-1) → N2-[4-tert-butyloxy-3S-(4-cyanophenylthio)-2S-isobutylsuccinyl]-L-tert-leucine-N1-methylamide (198421-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / -78 °C

1.2: 50 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 74 percent / HOBT; N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; DMAP / dimethylformamide / 20 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Condensation / 2.1: Condensation;

DOI:10.1021/jm990377j

Reference yield:

(R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid (112245-04-2) → N2-[4-tert-butyloxy-3S-(4-cyanophenylthio)-2S-isobutylsuccinyl]-L-tert-leucine-N1-methylamide (198421-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / -78 °C

1.2: 50 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 74 percent / HOBT; N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride; DMAP / dimethylformamide / 20 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Condensation / 2.1: Condensation;

DOI:10.1021/jm990377j

upstream raw materials:

(S)-2-amino-N,3,3-trimethylbutanamide

3S-(4-cyanophenylthio)-2S-isobutylbutan-1,4-dioic acid 4-tert-butyl ester

bis(4-cyanophenyl)disulfane

(R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid

Downstream raw materials:

N²-[3S-(4-cyanophenylthio)-4-hydroxy-2S-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 198421-68-0 N²-[4-tert-butyloxy-3S-(4-cyanophenylthio)-2S-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send