198474-58-7

Basic information

• Product Name: 3,5-dipentadecyloxybenzonitrile
• Synonyms: 3,5-dipentadecyloxybenzonitrile
• CAS NO: 198474-58-7
• Molecular Weight: 555.929
• Mol File: 198474-58-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,5-dipentadecyloxybenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dipentadecyloxybenzonitrile(198474-58-7)
• EPA Substance Registry System: 3,5-dipentadecyloxybenzonitrile(198474-58-7)

Safety Data

• Hazardous Substances Data: 198474-58-7(Hazardous Substances Data)

Upstream product

• 629-72-1 pentadecyl bromide 
• 19179-36-3 3,5-dihydroxycyanobenzene 

Relevant articles and documents

Renal-targeted delivery of triptolide by entrapment in pegylated TRX-20-modified liposomes

Previously, 3,5-dipentadecyloxybenzamidine hydrochloride (TRX-20)-modified liposomes were reported to specifically target mesangial cells (MCs) in glomeruli. To further gain a better understanding of the characteristics and potential application for glomerular diseases of TRX-20-modified liposomes, we synthesized TRX-20 and prepared TRX-20-modified liposomes (TRX-LPs) with different molar ratios - 6% (6%-TRX-LP), 11% (11%-TRX-LP), and 14% (14%-TRX-LP) - of TRX-20 to total lipid in the present study. All TRX-LPs exhibited concentration-dependent toxicity against the MCs at a lipid concentration ranging from 0.01 to 1.0 mg/mL with IC50 values of 3.45, 1.13, and 0.55 mg/mL, respectively. Comparison of the cell viability of TRX-LPs indicated that high levels of TRX-20 caused severe cell mortality, with 11%-TRX-LP showing the higher cytoplasmic accumulation in the MCs. Triptolide (TP) as a model drug was first loaded into 11%-TRX-LP and the liposomes were further modified with PEG5000 (PEG-TRX-TP-LP) in an attempt to prolong their circulation in blood and enhance TP-mediated immune suppression. Due to specific binding to MCs, PEG-TRX-TP-LP undoubtedly showed better anti-inflammatory action in vitro, evidenced by the inhibition of release of nitric oxide (NO) and tumor necrosis factor-α from lipopolysaccharide-stimulated MCs, compared with free TP at the same dose. In vivo, the PEG-TRX-TP-LP effectively attenuated the symptoms of membranous nephropathic (MN) rats and improved biochemical markers including proteinuria, serum cholesterol, and albumin. Therefore, it can be concluded that the TRX-modified liposome is an effective platform to target the delivery of TP to glomeruli for the treatment of MN.

Amidine derivatives and drug carriers comprising the same

Novel amidine derivatives of the formula (1); and drug carriers such as liposomes or emulsions comprising the derivatives, which can enclose genetic materials or drugs and transfer them to cells or affected sites efficiently and safely, wherein A is an aromatic ring, R1and R2are the same or different and independently represent an alkyl group having any one of 10 to 25 carbon atoms, and an alkenyl group having any one of 10 to 25 carbon atoms, X and Y are the same or different and independently represent —O—, —S—, —COO—, —OCO—, —CONH—, or —NHCO—, m is 0 or 1, and n is 0 or a natural number of 1 to 6.