19854-92-3

Usage

Uses

Used in Organic Synthesis:
Phenyl(1H-pyrazol-5-yl)methanone is used as a building block in organic synthesis for the creation of various biologically active compounds. Its unique structure allows for the development of new molecules with potential applications in different fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, phenyl(1H-pyrazol-5-yl)methanone is utilized as a key component in the synthesis of drugs. Its presence in the molecular structure can contribute to the desired pharmacological properties of the final product.
Used in Anti-inflammatory and Analgesic Applications:
Phenyl(1H-pyrazol-5-yl)methanone has been studied for its potential anti-inflammatory and analgesic properties. It may be used as an active pharmaceutical ingredient in the development of medications aimed at reducing inflammation and pain.
Used in Drug Development:
Phenyl(1H-pyrazol-5-yl)methanone has been identified as a potential scaffold for the development of new drugs. Its structure has shown promising results in medicinal chemistry studies, making it a valuable component in the design of innovative pharmaceuticals.

Upstream product

• 186581-53-3 diazomethane 
• 3623-15-2 phenyl propargyl ketone 
• 3306-07-8 1-benzoyl-2-chloroethene 
• 82706-88-5 5-Benzoyl-3,4-dihydro-2H-pyrazole-3-carbonitrile 
• 960-41-8 (E)-1-phenyl-3-(phenylsulfonyl)prop-2-en-1-one 
• 133228-23-6 1-(Dimethylsulfamoyl)-5-pyrazol 
• 1434140-10-9 ethyl 2-diazo-1-phenylbut-3-en-1-one 
• 141621-21-8 phenyl 1-<2-(trimethylsilyl)ethoxy>methyl-1H-pyrazole-5-yl ketone 
• 3282-32-4 2-diazo-acetophenone 
• 222718-47-0 (E)-3-(4-Chloro-benzenesulfonyl)-1-phenyl-propenone 
• 21860-48-0 (E)-1-phenyl-3-tosylprop-2-en-1-one 
• 325829-88-7 phenyl-[4-(toluene-4-sulfonyl)-4,5-dihydro-1H-pyrazol-3-yl]-methanone 
• 325829-87-6 [4-(4-chloro-benzenesulfonyl)-4,5-dihydro-1H-pyrazol-3-yl]-phenyl-methanone 
• 325829-86-5 (4-benzenesulfonyl-4,5-dihydro-1H-pyrazol-3-yl)-phenyl-methanone 

Relevant academic research and scientific papers

Gold(I)-Catalyzed Reactions between 2-(1-Alkynyl)-2-alken-1-ones and Vinyldiazo Ketones for Divergent Synthesis of Nonsymmetric Heteroaryl-Substituted Triarylmethanes: N-versus C-Attack Paths

Gold-catalyzed synthesis of nonsymmetrical heteroaryl-substituted triarylmethanes using 2-(1-alkynyl)-2-alken-1-ones and vinyldiazo ketones is described. In this catalytic sequence, vinyldiazo ketones attack gold-containing 3-furylbenzyl cations to form the observed C(1)-addition products. We also note that vinyldiazo ketones can be thermally cyclized to yield pyrazole derivatives, which can react with 3-furylbenzyl cations to afford pyrazole-containing triarylmethanes, corresponding to a N(5)-addition path.

Reactivity of Bifunctional Alkenes with Diazomethane

The cycloaddition of diazomethane to 1-aroyl-2-arylsulfonylethenes (1) and 1,2-bis(arylsulfonyl)ethenes (IV) under different conditions led to a variety of pyrazolines and pyrazoles. The reactivity of pyrazolines was also studied by pyrolysis, nitrosation and acylation.

4-Methoxybenzyl (PMB), a versatile protecting group for the regiospecific lithiation and functionalization of pyrazoles

The use of 4-methoxybenzyl (PMB) protecting group for the regiospecific metallation/functionalisation of pyrazole is reported.

THE METHYL FUNCTION AS SUITABLE N-1 PROTECTING GROUP IN LITHIATION REACTIONS WITH PYRAZOLES AND 1,2,4-TRIAZOLES

Metallation of 1-methyl-1H-pyrazole or 1-methyl-1H-1,2,4-triazole, respectively, with one equivalent of n-BuLi followed by reacrion with appropriate electrophiles leads to 5-substituted 1-2-(trimethylsi

Carbodesilylation of (Trimethylsilyl)imidazoles and -pyrazoles

The preparation of the 1-methyl(trimethylsilyl) (TMS)-substituted imidazoles 3a, 4a, 8, 9, and 11a by silylation of the corresponding metallated imidazoles is described.Carbodesilylation of 3 with aldehydes or carboxylic halogenides occurs selectively in 2-position.In the presence of a strong base (CsF) the reactivity against carbon electrophiles correlates well with the stability of the imidazolyl anions; regioselective carbodesilylation in 2-, 5-, or 4-position of the twofold TMS-substituted imidazoles 3a and 9 therefore is possible, which allows the synthesis of a great variety of hydroxyalkyl-substituted imidazoles and of acylimidazoles.By using the dimethylsulfamoyl substituent as an N-protecting group, the N-unsubstituted 5-benzoylimidazole (26) as well as the comparable 5-benzoyl-pyrazole (30b) and 5-(hydroxyphenylmethyl)pyrazole (30a) are accessible. Key Words : Imidazoles, (trimethylsilyl)-, carbodesilylation of / Pyrazoles, (trimethylsilyl)-, carbodesilylation of / Carbodesilylation

Effective Methods for the Syntheses of 2-Pyrazolines and Pyrazoles from Diazocarbonyl Compounds

Dipolar addition of diazocarbonyl compounds to α,β-unsaturated esters and nitriles in the presence of pyridine results in the production 2-pyrazolines in nearly quantitative yields.In one case, reaction of α-diazoacetophenone with acrylonitrile, Michael addition of the 2-pyrazoline to the conjugated olefin is observed, but this process is minimized by limiting the amount of pyridine employed. 5-Cyano-2-pyrazolines are converted to derivative pyrazoles through alkoxide promoted hydrogen cyanide elimination.With vinyl sulfone, α-diazoacetophenone undergoes sequential dipolar addition, Michael addition, and vinyl sulfite elimination under exceptionally mild conditions to form the derivative β-(1-pyrazolyl)ethyl vinyl sulfone in good yield.