198543-96-3

Usage

Uses

Used in Biochemical Research:
Fmoc-D-Chg-OH is used as a protective agent for the amine group in the synthesis of peptides, proteins, and other organic compounds. Its primary application is in solid-phase peptide synthesis, where it plays a vital role in the stepwise construction of peptide chains.
Used in Pharmaceutical Industry:
Fmoc-D-Chg-OH is used as a building block in the synthesis of complex peptide-based drugs. Its protective Fmoc group allows for the controlled and efficient assembly of peptide sequences, which is essential for the development of new therapeutic agents.
Used in Academic Research:
Fmoc-D-Chg-OH is employed as a research tool in academic institutions, where it is used to study the structure and function of peptides and proteins. Its applications in this field include the investigation of protein-protein interactions, enzyme mechanisms, and the development of novel bioactive peptides.
Used in Diagnostics:
Fmoc-D-Chg-OH is used in the development of diagnostic tools, such as immunoassays and biosensors, where specific peptide sequences are required for the detection and quantification of target molecules. Its role in peptide synthesis enables the production of highly specific and sensitive diagnostic reagents.

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 14328-51-9 (2S)-amino(cyclohexyl)ethanoic acid 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Relevant academic research and scientific papers

Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate-Directed Formation of Quinolones versus Quinazolinones

Previous studies showed that the FeII/α-ketoglutarate dependent dioxygenase AsqJ induces a skeletal rearrangement in viridicatin biosynthesis in Aspergillus nidulans, generating a quinolone scaffold from benzo[1,4]diazepine-2,5-dione substrates. We report that AsqJ catalyzes an additional, entirely different reaction, simply by a change in substituent in the benzodiazepinedione substrate. This new mechanism is established by substrate screening, application of functional probes, and computational analysis. AsqJ excises H2CO from the heterocyclic ring structure of suitable benzo[1,4]diazepine-2,5-dione substrates to generate quinazolinones. This novel AsqJ catalysis pathway is governed by a single substituent within the complex substrate. This unique substrate-directed reactivity of AsqJ enables the targeted biocatalytic generation of either quinolones or quinazolinones, two alkaloid frameworks of exceptional biomedical relevance.

EPHA4 CYCLIC PEPTIDE ANTAGONISTS AND METHODS OF USE THEREOF

Disclosed herein are compounds and methods of use thereof for the modulation of EphA4 receptor activity. In an aspect, is provided a method of treating or preventing a disease or disorder mediated by EphA4, comprising administering to a subject in need thereof a therapeutically effective amount of a compound as described herein, including certain embodiments, or the structural Formula (I), (l-A), (II), (III), (IV), (IV-1), (V), (Vl-A), (Vl-B), (VII-1), (VII-2), (VIII-1), or (VIII-2), or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, or hydrate thereof.

Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins

A streamlined total synthesis of N14-desacetoxytubulysin H (Tb1) based on a C-H activation strategy and a short total synthesis of pretubulysin D (PTb-D43) are described. Applications of the developed synthetic strategies and technologies to the synthesis of a series of tubulysin analogues (Tb2-Tb41 and PTb-D42) are also reported. Biological evaluation of the synthesized compounds against an array of cancer cells revealed a number of novel analogues (e.g., Tb14), some with exceptional potencies against certain cell lines [e.g., Tb32 with IC50 = 12 pM against MES SA (uterine sarcoma) cell line and 2 pM against HEK 293T (human embryonic kidney) cell line], and a set of valuable structure-activity relationships. The highly potent cytotoxic compounds discovered in this study are highly desirable as payloads for antibody-drug conjugates and other drug delivery systems for personalized targeted cancer chemotherapies.