198549-12-1

Upstream product

• 143209-16-9 ethyl 2,3-dioxopropanoate 3-hydrazone 
• 791856-59-2 4-(2-phenylimidazol-1-yl)thiobutyramide 
• 670-96-2 2-Phenylimidazole 
• 5332-06-9 4-bromobutanenitrile 

Downstream Products

• 198549-21-2 3-(3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine 
• 1622292-57-2 4-(2-phenyl-1H-imidazol-1-yl)butanimidhydrazide 
• 1622292-56-1 7-(6,7-di-p-tolyl-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)heptanoic acid 
• 1671058-41-5 ethyl 7-(6,7-di-p-tolyl-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)heptanoate 
• 1622292-59-4 6,7-di-p-tolyl-1 ,2,3,4-tetrahydro-1 ,5-naphthyridine 
• 1622292-58-3 3-(3-(2-phenyl-1H-imidazol-1-yl)propyl)-5,6-di-p-tolyl-1,2,4-triazine 
• 791856-46-7 3-(3-(2-phenylimidazol-1-yl)propyl)-5-phenyl-1,2,4-triazine 
• 791856-68-3 6-(4-bromophenyl)-1,2,3,4-tetrahydro-1,5-naphthyridine 
• 791856-69-4 6-(4-methoxyphenyl)-1,2,3,4-tetrahydro-1,5-naphthyridine 
• 791856-65-0 6-phenyl-1,2,3,4-tetrahydro-1,5-naphthyridine 
• 198549-17-6 5,6-diphenyl-3-(3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine 
• 198549-20-1 5,6-dimethyl-3-(3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine 
• 198549-22-3 6,7-diphenyl-1,2,3,4-tetrahydro-1,5-naphthyridine 
• 13993-61-8 1.1,2,3,4-tetrahydro-1,5-naphthyridine 

Relevant academic research and scientific papers

IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS

The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various or

Intramolecular inverse-electron-demand Diels-Alder reactions of imidazoles with 1,2,4-triazines: A new route to 1,2,3,4-tetrahydro-1,5-naphthyridines and related heterocycles

The intramolecular inverse-electron-demand Diels-Alder reaction between imidazoles and 1,2,4-triazines linked by a trimethylene tether from the imidazole N1 position to the triazine C3 proceed in excellent yields to produce 1,2,3,4-tetrahydro-1,5-naphthyridines. The reaction proceeds by a cycloaddition with subsequent loss of nitrogen, followed by a presumed stepwise loss of a nitrile. The analogous intramolecular cycloadditions employing a tetramethylene tether also proceeded to give 2,3,4,5-tetrahydro-1H-pyrido[3,2-b]azepines in acceptable yields. The reaction to produce the tetrahydro-1,5-naphthyridines can also be promoted with microwave irradiation.

Dienophilicity of imidazole in inverse electron demand Diels-Alder reactions; intramolecular reactions with 1,2,4-triazines

Imidazole and 2-phenylimidazole undergo intramolecular cycloadditions with 1,2,4-triazines tethered between an imidazole nitrogen and the triazinyl C3 position with a trimethylene chain to produce tetrahydro-1,5-naphthyridines following loss of N2/s