198555-45-2

Upstream product

• 96-32-2 bromoacetic acid methyl ester 
• 198555-41-8 (5-ethyl-2,6-dimethoxypyrimidin-4-yl)(phenyl)methanone 
• 1780-38-7 2,4,6-trichloro-5-ethylpyrimidine 
• 120268-44-2 5-ethyl-6-chloro-2,4-dimethoxypyrimidine 
• 171048-64-9 6-(α-cyanobenzyl)-2,4-dimethoxy-5-ethylpyrimidine 

Relevant academic research and scientific papers

5,6-Dihydropyrrolo[1,2-c]pyrimidine-1,3(2H,5H)-diones as annulated analogues of the anti-HIV compound MKC-442 (6-benzyl-1-(ethoxymethyl)-5-isopropyluracil)

Annulated analogues of the anti-HIV compound MKC-442 were synthesized from 6-benzoyl-5-ethyl-2,4-dimethoxypyrimidine (4) by reaction with Zn/NH4Cl and 3-bromopropene. The intermediate homoallylic alcohol is subjected to a ring closure reaction by treatment with bromine either directly or after O-benzylation to give 5,6-dihydropyrrolo[1,2-c]pyrimidinones. No activity against HIV was observed, neither for the annulated analogues nor the derivatives synthesized from 4. Only compound 4 showed activity against HIV-1.