198555-56-5

Basic information

• Product Name: 4-O-benzyl-4-(2,4-dimethoxy-5-ethylpyrimidin-6-yl)butane-1,2,4-triol
• Synonyms: 4-O-benzyl-4-(2,4-dimethoxy-5-ethylpyrimidin-6-yl)butane-1,2,4-triol
• CAS NO: 198555-56-5
• Molecular Weight: 438.524
• Mol File: 198555-56-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-O-benzyl-4-(2,4-dimethoxy-5-ethylpyrimidin-6-yl)butane-1,2,4-triol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-O-benzyl-4-(2,4-dimethoxy-5-ethylpyrimidin-6-yl)butane-1,2,4-triol(198555-56-5)
• EPA Substance Registry System: 4-O-benzyl-4-(2,4-dimethoxy-5-ethylpyrimidin-6-yl)butane-1,2,4-triol(198555-56-5)

Safety Data

• Hazardous Substances Data: 198555-56-5(Hazardous Substances Data)

Upstream product

• 171048-64-9 6-(α-cyanobenzyl)-2,4-dimethoxy-5-ethylpyrimidine 
• 198555-42-9 2,4-dimethoxy-5-ethyl-6-(1-hydroxy-1-phenylbut-3-enyl)pyrimidine 
• 198555-41-8 (5-ethyl-2,6-dimethoxypyrimidin-4-yl)(phenyl)methanone 
• 120268-44-2 5-ethyl-6-chloro-2,4-dimethoxypyrimidine 
• 1780-38-7 2,4,6-trichloro-5-ethylpyrimidine 
• 198555-43-0 6-(1-benzyloxy-1-phenylbut-3-enyl)-5-ethyl-2,4-dimethoxypyrimidine 

Relevant articles and documents

5,6-Dihydropyrrolo[1,2-c]pyrimidine-1,3(2H,5H)-diones as annulated analogues of the anti-HIV compound MKC-442 (6-benzyl-1-(ethoxymethyl)-5-isopropyluracil)

Annulated analogues of the anti-HIV compound MKC-442 were synthesized from 6-benzoyl-5-ethyl-2,4-dimethoxypyrimidine (4) by reaction with Zn/NH4Cl and 3-bromopropene. The intermediate homoallylic alcohol is subjected to a ring closure reaction by treatment with bromine either directly or after O-benzylation to give 5,6-dihydropyrrolo[1,2-c]pyrimidinones. No activity against HIV was observed, neither for the annulated analogues nor the derivatives synthesized from 4. Only compound 4 showed activity against HIV-1.