19858-50-5

Basic information

• Product Name: 5-Pyrimidinemethanol, 2-(methylthio)- (8CI,9CI)
• Synonyms: 5-Pyrimidinemethanol, 2-(methylthio)- (8CI,9CI);(2-(Methylthio)pyriMidin-5-yl)Methanol;5-Hydroxymethyl-2-methylthiopyrimidine;5-Pyrimidinemethanol,2-(methylthio)-;2-(methylthio)-5-Pyrimidinemethanol
• CAS NO: 19858-50-5
• Molecular Formula: C6H8N2OS
• Molecular Weight: 156.20552
• Product Categories: PYRIMIDINE
• Mol File: 19858-50-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 59-61℃
• Appearance: /
• Density: 1.30±0.1 g/cm3 (20 oC 760 Torr), Calc.*
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Pyrimidinemethanol, 2-(methylthio)- (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinemethanol, 2-(methylthio)- (8CI,9CI)(19858-50-5)
• EPA Substance Registry System: 5-Pyrimidinemethanol, 2-(methylthio)- (8CI,9CI)(19858-50-5)

Safety Data

• Hazardous Substances Data: 19858-50-5(Hazardous Substances Data)

Usage

General Description

5-Pyrimidinemethanol, 2-(methylthio)- (8CI,9CI) is a chemical compound with the molecular formula C7H10N2OS. It is also known as 2-(Methylthio)pyrimidine-5-methanol and has a molecular weight of 170.23 g/mol. 5-Pyrimidinemethanol, 2-(methylthio)- (8CI,9CI) is a pyrimidine derivative containing a hydroxymethyl group and a methylthio group. It may have potential applications in pharmaceuticals, organic synthesis, and agrochemicals. However, it is important to handle this substance with caution, as its properties and potential hazards have not been extensively studied.

Upstream product

• 38275-41-1 methyl 2-(methylthio)pyrimidine-5-carboxylate 
• 73781-88-1 ethyl 2-(methylthio)pyrimidine-5-carboxylate 

Downstream Products

• 323591-23-7 5-(bromomethyl)-2-(methylsulfanyl)pyrimidine 

Relevant articles and documents

cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention is directed to quinoline amide compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

Reduction of pyrimidine derivatives by LiAlH4

The reduction of ethyl 2-methylthio-(or 2-ethoxy)pyrimidine-5-carboxylate by LiAlH4 afforded ethyl 2-methylthio-(or 2-ethoxy)-1,6- dihydropyrimidine-5-carboxylate as the main product. Similarly, the reduction of 2-methylthio-(or 2-methoxy)pyrimidine-5-carboxamide by LiAlH4 gave 2-methylthio-(or 2-methoxy)-1,6-dihydropyrimidine-5-carbonitrile as main product.