198632-96-1Relevant academic research and scientific papers
Synthesis of β-CF3 ketones from trifluoromethylated allylic alcohols by ruthenium catalyzed isomerization
Bizet, Vincent,Pannecoucke, Xavier,Renaud, Jean-Luc,Cahard, Dominique
supporting information, p. 56 - 61 (2013/11/06)
This work describes the optimization process for the synthesis of β-trifluoromethylated ketones from trifluoromethylated allylic alcohols. This transformation proceeds through a ruthenium catalyzed isomerization under mild conditions with high atom econom
CHEMICAL COMPOUNDS
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Page/Page column 97, (2010/02/15)
The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel naphthalene compounds that are particularly useful for selective estrogen receptor modulation.
AMINE-BASED AND AMIDE-BASED INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) ENZYME ACTIVITY AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT OF DISEASES
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Page/Page column 92, (2010/02/13)
Compositions and methods are disclosed for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1). The compounds disclosed are amine-containing and amide-containing compounds. The compounds and compositions are useful for treatment of diseases, including inflammation, inflammatory diseases and autoimmune disorders.
Synthesis of 4--3-(trifluoromethyl)butanoic acid
Coe, Paul L.,Markou, Magdalini,Tatlow, John Colin
, p. 112 - 118 (2007/10/03)
Benzyl trifluoromethyl ketone and ethyl bromoacetate afforded ethyl 3-hydroxy-4-phenyl-3-(trifluoromethyl)butanoate in a Reformatsky-type reaction.This hydroxy ester, by successive stages of dehydration to a but-2-enoate, hydrogenation of the double bond,
