198632-97-2

Upstream product

• 198632-96-1 (E)-ethyl 3-benzyl-4,4,4-trifluorobut-2-enoate 
• 350-92-5 1,1,1-Trifluoro-3-phenylpropan-2-one 
• 872550-40-8 (Z)-ethyl 3-benzyl-4,4,4-trifluorobut-2-enoate 
• 198632-95-0 3-Benzyl-4,4,4-trifluoro-3-hydroxy-butyric acid ethyl ester 

Downstream Products

• 198632-98-3 4,4,4-Trifluoro-3-(4-nitro-benzyl)-butyric acid ethyl ester 
• 198632-99-4 3-(4-Amino-benzyl)-4,4,4-trifluoro-butyric acid ethyl ester 
• 198633-01-1 3-{4-[Bis-(2-chloro-ethyl)-amino]-benzyl}-4,4,4-trifluoro-butyric acid ethyl ester 
• 198633-00-0 3-{4-[Bis-(2-hydroxy-ethyl)-amino]-benzyl}-4,4,4-trifluoro-butyric acid ethyl ester 
• 872550-41-9 4,4,4-trifluoro-3-(phenylmethyl)butanoic acid 

Relevant academic research and scientific papers

CHEMICAL COMPOUNDS

The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel naphthalene compounds that are particularly useful for selective estrogen receptor modulation.

Synthesis of 4--3-(trifluoromethyl)butanoic acid

Benzyl trifluoromethyl ketone and ethyl bromoacetate afforded ethyl 3-hydroxy-4-phenyl-3-(trifluoromethyl)butanoate in a Reformatsky-type reaction.This hydroxy ester, by successive stages of dehydration to a but-2-enoate, hydrogenation of the double bond,