198633-78-2Relevant academic research and scientific papers
3,4-dihydro-1-isoquinolinamines: A novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency
Beaton, Haydn,Hamley, Peter,Nicholls, David J,Tinker, Alan C,Wallace, Alan V
, p. 1023 - 1026 (2001)
3-Phenyl-3,4-dihydro-1-isoquinolinamine is a weak inhibitor of iNOS and nNOS. Structural variation of 5a results in inhibitors with a range of potency and selectivity for the NOS enzymes, including a potent and very selective iNOS inhibitor 5j.
Aminoisoquinolines and aminotheinopyridine derivatives and their use as anti-inflammatory agents
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, (2008/06/13)
PCT No. PCT/SE97/00589 Sec. 371 Date Aug. 19, 1997 Sec. 102(e) Date Aug. 19, 1997 PCT Filed Apr. 9, 1997 PCT Pub. No. WO97/38977 PCT Pub. Date Oct. 23, 1997Compounds of formula I wherein R, R1, R2, and R3 and A are as defined herein, together with pharmaceutically acceptable salts, enantiomers or tautomers are useful as pharmaceuticals, particularly in the treatment of inflammatory disease.
