Cas 950509-80-5,[(R)-1-((R)-1-isopropyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-ylcarbamoyl)-2-(2-trifluoromethoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

950509-80-5

Post Buying Request

Basic information

Product Name: [(R)-1-((R)-1-isopropyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-ylcarbamoyl)-2-(2-trifluoromethoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester
Synonyms: [(R)-1-((R)-1-isopropyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-ylcarbamoyl)-2-(2-trifluoromethoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester
CAS NO:950509-80-5
Molecular Formula:
Molecular Weight: 549.59
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: [(R)-1-((R)-1-isopropyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-ylcarbamoyl)-2-(2-trifluoromethoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
NIST Chemistry Reference: [(R)-1-((R)-1-isopropyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-ylcarbamoyl)-2-(2-trifluoromethoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester(950509-80-5)
EPA Substance Registry System: [(R)-1-((R)-1-isopropyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-ylcarbamoyl)-2-(2-trifluoromethoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester(950509-80-5)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 950509-80-5(Hazardous Substances Data)

Suppliers
Usage
Upstream product
Downstream Products
Article

950509-80-5 Suppliers

Recommended suppliers

950509-80-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 950509-80-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,0,5,0 and 9 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 950509-80:
(8*9)+(7*5)+(6*0)+(5*5)+(4*0)+(3*9)+(2*8)+(1*0)=175
175 % 10 = 5
So 950509-80-5 is a valid CAS Registry Number.

950509-80-5Upstream product

950509-80-5Downstream Products

950509-80-5Relevant academic research and scientific papers

Benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

Hoyt, Scott B.,London, Clare,Ok, Hyun,Gonzalez, Edward,Duffy, Joseph L.,Abbadie, Catherine,Dean, Brian,Felix, John P.,Garcia, Maria L.,Jochnowitz, Nina,Karanam, Bindhu V.,Li, Xiaohua,Lyons, Kathryn A.,McGowan, Erin,MacIntyre, D. Euan,Martin, William J.,Priest, Birgit T.,Smith, McHardy M.,Tschirret-Guth, Richard,Warren, Vivien A.,Williams, Brande S.,Kaczorowski, Gregory J.,Parsons, William H.

, p. 6172 - 6177 (2007)

A series of benzazepinones were synthesized and evaluated as hNav1.7 sodium channel blockers. Several compounds from this series displayed good oral bioavailability and exposure and were efficacious in a rat model of neuropathic pain.

A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain

Hoyt, Scott B.,London, Clare,Abbadie, Catherine,Felix, John P.,Garcia, Maria L.,Jochnowitz, Nina,Karanam, Bindhu V.,Li, Xiaohua,Lyons, Kathryn A.,McGowan, Erin,Priest, Birgit T.,Smith, McHardy M.,Warren, Vivien A.,Thomas-Fowlkes, Brande S.,Kaczorowski, Gregory J.,Duffy, Joseph L.

, p. 3640 - 3645 (2013/07/11)

A series of benzazepinones were synthesized and evaluated for block of Nav1.7 sodium channels. Compound 30 from this series displayed potent channel block, good selectivity versus other targets, and dose-dependent oral efficacy in a rat model of neuropathic pain.

BENZAZEPINONES AS SODIUM CHANNEL BLOCKERS

-

, (2008/06/13)

Benzazepinone compounds represented by Formula (I), or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically act

Discovery of a novel class of benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

Hoyt, Scott B.,London, Clare,Gorin, David,Wyvratt, Matthew J.,Fisher, Michael H.,Abbadie, Catherine,Felix, John P.,Garcia, Maria L.,Li, Xiaohua,Lyons, Kathryn A.,McGowan, Erin,MacIntyre, D. Euan,Martin, William J.,Priest, Birgit T.,Ritter, Amy,Smith, McHardy M.,Warren, Vivien A.,Williams, Brande S.,Kaczorowski, Gregory J.,Parsons, William H.

, p. 4630 - 4634 (2008/02/10)

A series of benzodiazepines and benzazepinones were synthesized and evaluated as potential sodium channel blockers in a functional, membrane potential-based assay. One member of the benzazepinone series, compound 47, displayed potent, state-dependent block of hNav1.7, and was orally efficacious in a rat model of neuropathic pain.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 950509-80-5