198710-92-8

Upstream product

• 1191124-98-7 C₂₉H₂₄Cl₂NO₇P 
• 1191124-92-1 C₂₄H₃₂N₂O₁₀ 
• 1191124-99-8 C₄₁H₄₅Cl₂N₃O₁₃ 
• 1602827-88-2 C₂₈H₃₇N₃O₁₂ 
• 354575-15-8 3,5-dichloro-4-benzoxybenzoic chloride 
• 41490-13-5 4-(benzyloxy)-3,5-dichlorobenzoicacid 
• 420107-66-0 (S)-2-(4-Benzyloxy-3,5-dichloro-benzoylamino)-3-hydroxy-propionic acid benzyl ester 
• 866331-49-9 (2R)-1-tert-butyl 2-formyl-5-oxopyrrolidine-1,2-dicarboxylate methyl ester 
• 866331-50-2 (R)-2-Hydroxymethyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 
• 420107-70-6 (2R,5R)-2-((1S,2R)-2-Benzyloxycarbonylamino-2-carboxy-1-hydroxy-ethyl)-5-[(S)-2-benzyloxycarbonyl-2-(4-benzyloxy-3,5-dichloro-benzoylamino)-ethyl]-pyrrolidine-1,2-dicarboxylic acid dibenzyl ester 
• 1438408-41-3 C₂₆H₂₃Cl₂N₅O₁₀ 
• 1438408-40-2 C₂₆H₂₉Cl₂N₅O₇ 
• 1438408-39-9 C₂₀H₃₃N₅O₇ 

Downstream Products

• 1010808-39-5 kaitocephalin diethylammonium salt 

Relevant academic research and scientific papers

A concise [C+NC+CC] coupling-enabled synthesis of kaitocephalin

A 15-step synthesis of the iGluR antagonist kaitocephalin from aspartic acid is reported. The linchpin pyrrolidine ring of the target molecule is efficiently assembled with in a single operation via an asymmetric [C+NC+CC] reaction.

Total synthesis of (-)-kaitocephalin

(-)-Kaitocephalin has been synthesized. With the C9 stereocenter from Garner's aldehyde, the C4 quaternary carbon was installed by the desymmetrization of the Cbz-protected serinol. The remaining stereogenic centers were generated through mercuriocyclizat

Reinvestigation on total synthesis of kaitocephalin and its isomers

Aldol reaction of 2,5-disubstituted pyrrolidine 3b with (R)-Garner aldehyde followed by Sharpless asymmetric dihydroxylation and other four reactions afforded mesylate 8a, which was introduced by an amide group via three ordinary transformations to provid

Total synthesis of (-)-kaitocephalin

(Chemical Equation Presented) Total synthesis of the potent AMPA/KA receptor antagonist (-)-kaitocephalin (1) and its three diastereomers has been accomplished. The synthesis features strictly substrate-controlled operations to α-formylglutamate 3 startin

The first synthesis of kaitocephalin based on the structure revision

A total synthesis of kaitocephalin (2), a glutamate receptor antagonist, was accomplished employing a novel stereoselective C-C bond forming reaction of a nitrone (8) and a halide (11) with zinc in aqueous solvent under sonication as a key step. The absolute configuration of kaitocephalin was confirmed to be 2R,3S,4R,7R,9S.