198835-04-0

Basic information

• Product Name: 6-OXO-2-AZA-BICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 6-OXO-2-AZA-BICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER;2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 6-oxo-, 1,1-dimethylethyl ester
• CAS NO: 198835-04-0
• Molecular Formula: C11H17NO3
• Molecular Weight: 211.25758
• Mol File: 198835-04-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 84 °C
• Boiling Point: 308.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.173±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.10±0.20(Predicted)
• CAS DataBase Reference: 6-OXO-2-AZA-BICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6-OXO-2-AZA-BICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER(198835-04-0)
• EPA Substance Registry System: 6-OXO-2-AZA-BICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER(198835-04-0)

Safety Data

• Hazardous Substances Data: 198835-04-0(Hazardous Substances Data)

Usage

General Description

6-OXO-2-AZA-BICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER is a chemical compound with a complex and specific molecular structure. It is a tert-butyl ester of a bicyclic carboxylic acid containing an oxo group and an azabicyclic ring system. 6-OXO-2-AZA-BICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID TERT-BUTYL ESTER may have potential applications in pharmaceuticals, as its unique structure could potentially contribute to specific biological activities. The specific properties and potential uses of this chemical compound would require further research and testing to fully understand its capabilities and effects.

Upstream product

• 149494-50-8 (-)-(1S,1'R)-2-(1'-Phenylethyl)-2-azabicyclo<2.2.1>hept-5-ene 
• 702666-72-6 tert-butyl (1S,4R)-2-azabicyclo[2.2.1]heptan-5-en-2-carboxylate 
• 130931-83-8 (1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one 
• 198835-01-7 (1S,4R,6S)-tert-butyl 6-hydroxy-2-azabicyclo[2,2,1]heptane-2-carboxylate 
• 1099570-25-8 tert-butyl (1RS,4SR,6RS)-6-hydroxy-2-azabicyclo[2.2.1] heptane-2-carboxylate 
• 542-92-7 cyclopenta-1,3-diene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1099570-25-8 6-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 198835-02-8 C₁₁H₁₉NO₃ 
• 1099570-25-8 tert-butyl 6-hydroxy-2-azabicyclo[2,2,1]heptane-2-carboxylate 
• 188345-71-3 2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]hept-5-ene 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 1005077-74-6 (1S,4S,6R)-tert-butyl 6-amino-2-azabicyclo[2,2,1]heptane-2-carboxylate 

Relevant articles and documents

HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein HET, R1, R2, R3, R4, R5, L, L1, X1, X2, X3 and q are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds; and intermediates useful in the preparation of the compounds.

Synthesis and biological evaluation of pyrimidine derivatives with diverse azabicyclic ether/amine as novel GPR119 agonist

A class of novel pyrimidine derivatives bearing diverse conformationally restricted azabicyclic ether/amine were designed, synthesized and evaluated for their GPR119 agonist activities against type 2 diabetes. Most compounds exhibited superior hEC50

Synthesis of novel azanorbornylpurine derivatives

Azanorbornylpurine derivatives were prepared by Mitsunobu reaction of appropriate hydroxyazanorbornane derivative with 6-chloropurine or construction of purine base at azanorbornylamines. The prepared target compounds were evaluated for antiviral activity and effect on neuronal and muscle nicotinic acetylcholine receptors.