19891-75-9

Upstream product

• 37905-02-5 (2E,6E)-3,7-dimethyl-8-oxoocta-2,6-dien-1-yl acetate 
• 40772-85-8 (2E,6E-dimethylocta-2,6-dienoic acid methyl ester)triphenylphosphonium bromide 
• 856683-48-2 8-bromo-2,6-dimethylocta-2,6-dienoic acid methyl ester 
• 40772-83-6 2,6-trans-2,6-dimethyl-8-hydroxy-2,6-octadienoic acid methyl ester 
• 26187-80-4 2,6-trans-2,6-dimethyl-8-hydroxy-2,6-octadienoic acid 
• 83852-61-3 (2E,6E)-8-acetoxy-2,6-dimethylocta-2,6-dienoic acid 
• 105-87-3 3,7-dimethyl-2E,6-octadien-1-yl acetate 
• 40772-87-0 dimethyl Ψ,Ψ-carotene-16,16'-dioate 

Downstream Products

• 914359-41-4 C₄₇H₆₄O₈P₂ 
• 914359-40-3 C₆₁H₇₆O₈P₂ 
• 882491-48-7 C₆₈H₈₂O₈P₂ 

Relevant academic research and scientific papers

Efficient total synthesis of lycophyll (ψ,ψ-carotene-16,16′- diol)

A practical procedure is described for the total synthesis of lycophyll (16,16′-dihydroxy-lycopene; ψ,ψ-carotene-16,16′-diol), based on a C10 + C20 + C10 synthetic methodology using the commercially available materials geraniol (C10) and crocetin-dialdehyde (C20). A late-stage double Wittig olefination on crocetindialdehyde was used to form the desired lycophyll scaffold in eight linear synthetic steps, while generating a mixture of polyenic geometric isomers that could be effectively separated using HPLC. All-trans lycophyll was subsequently separated to >95% purity by semipreparative chromatography using a C30 carotenoid column.

Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates

A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.

METHODS FOR SYNTHESIS OF CHIRAL INTERMEDIATES OF CAROTENOIDS, CAROTENOID ANALOGS, AND CAROTENOID DERIVATIVES

A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids.