199008-83-8

Upstream product

• 114671-83-9 1-(t-butyldiphenylsilyloxy)-3-iodopropane 
• 127047-71-6 3-(tert-butyldiphenylsilyloxy)propan-1-ol 
• 808766-10-1 (S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-pentanoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide 
• 1036278-64-4 (tert-butyldiphenylsilyl) (S)-5-(tert-butyldimethylsilyloxy)-4-methylpentan-1-yl ether 

Downstream Products

• 1449467-81-5 C₄₄H₅₉NO₆SSi 
• 1449467-83-7 C₂₆H₃₈O₄Si 
• 1449467-84-8 C₃₄H₅₀O₇Si 
• 199008-92-9 Methanesulfonic acid (1R,2S)-5-(tert-butyl-diphenyl-silanyloxy)-2-methyl-1-((S)-1-methyl-allyl)-pentyl ester 
• 199008-89-4 (3S,4R,5S)-8-(tert-Butyl-diphenyl-silanyloxy)-3,5-dimethyl-oct-1-en-4-ol 
• 199008-98-5 (7R,9S)-12-(4-Methoxy-benzyloxy)-7,9-dimethyl-dodec-3-yn-5-ol 
• 199008-81-6 (3R,5S)-8-(4-Methoxy-benzyloxy)-3,5-dimethyl-octanal 
• 199008-96-3 1-((4S,6R)-4,6-Dimethyl-oct-7-enyloxymethyl)-4-methoxy-benzene 
• 199008-86-1 (S)-5-(tert-butyldiphenylsilyloxy)-2-methylpentanal 

Relevant academic research and scientific papers

Synthetic studies on the nhatrangins: Stereoselective access to an advanced aldehyde intermediate

Two different strategies have been considered to achieve the first total synthesis of nhatrangins A and B. The first approach based on a cross metathesis (CM) reaction was unsuccessful. The second, which combined a highly stereoselective alkylation, a diastereoselective aldolization, and finally an esterification, furnished an advanced aldehyde intermediate bearing the three contiguous stereogenic centres and the expected side-chain. Two strategies have been considered for the stereoselective synthesis of nhatrangins A and B. A sequence involving diastereoselective alkylation and aldolization employing ephedrine derivatives as chiral auxiliaries was the most efficient approach to deliver a key aldehyde framework. Copyright

Synthesis of (S)-jamaicamide C carboxylic acid

"Chemical Equation Presented" The jamaicamides are natural product sodium channel blockers derived from the cyanobacterium Lyngbya majuscula. The carboxylic acid fragment of jamaicamide C contains a methyl stereocenter and a trisubstituted E chloroolefin.

Furan derivatives, method of synthesis and uses thereof

The present invention relates to furan derivatives of formula (I), their method of synthesis and uses thereof. Concretely, the compounds disclosed have proved to be inhibitors of glycogen synthase kinase 3β, GSK-3 β, which is known to be involved in different disease and conditions, such as Alzheimer's disease or non-insulin dependent diabetes mellitus. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a GSK-3 mediated disease or condition.